Synthesis of some thiazole and phthalazine compounds from schiff bases

Abstract

It was known that heterocyclic compounds containing S and N have considerable importance which withdraw researchers attention due to their wide medical and biological applications. In the present investigation we have synthesized some oxadiazole derivatives (A 9-15 ), phthalazine derivatives (A 33-38 ) and Benzo thiazole-2-yl arylthiazol-4-one (A 17-24 ), thiazoles (A 39-41 ) from schiff base precursors. The thiazole compounds were cyclized using acetic anhydride, thioglycolic acid while phthalazines were cyclized using amylalcohol in HCl. The synthesized compounds were studied by IR,1HNMR spectral methods. ExperimentalPhenyl hydrazide (0.01mol.) or 3-Nitrophenyl hydrazide was dissolved in 25 ml of absolute ethanol. Aldehyde or its derivatives was then added. The reaction mixture was refluxed for 2 hours, cooled,stand for 3 hour at r.t. The p.p.t was filtered off and crystallized from ethanol, Physical and IR spectral data were shown in Tables 1,2.Synthesis of (substituted phenyl, substituted benzoyl hydrazonel(A 2-8

Synthesis Of Some Heterocyclic Compounds Derived From Ortho-Carboxybenzaldehyde

“…Note the compound 12 use the double of moles of triethylamine and chloroacetyl chloride. [14,15] (0.001 mol) of Schiff bases 1-6 in abs-ethanol (20 ml) was added (0.1 ml, 0.001 mole) of thioglycolic acid in presence of anhydrous zinc chloride ( 0.14 gm, 0.001 mole ). The mixture was reflux for 10 hrs (monitored by TLC) the solvent system is (4:1) benzene: MeOH, After completion, the mixture poured into crushed ice, then treated with potassium carbonate with stirring to obtain the product, then filtered and recrystallized from ethanol.…”