Nanocomposite has gain great attention in many applications due to its better properties in nanoscale. Chitosan-Zeolite-ZnO nanocomposite were prepared via sol-gel method and were analysed by molecular docking study to predict its antiviral activity against SARS CoV-2. The SARS CoV-2 glycoprotein as receptor from RCSB PDB and complex ligand of Chitosan-Zeolite and ZnO were chosen as interaction model between ligand and receptor. According to free binding energy, it was found that chitosan has better potency in nanocomposite against SARS Cov-2.