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Abstract. Practical decision of infectology problem depends on the correct assessment of the main concepts of epidemiology and microbiology. The feasibility of attracting the attention of specialists in related disciplines to the problem of microbiological monitoring is discussed. In connection with the capabilities of highly sensitive molecular methods and mathematical modeling on the example of microbiological monitoring of Yersinia was made attempt to analyse mod- ern opportunities of bacteriology and to enter a predictive component as an important element of purposeful activity into monitoring definition. Yersiniosis are one of the most urgent infectious diseases. A variety of biological properties of Yersinia, their various epidemiological importance (Yersinia spp. enter into I, III and the IV groups of virulence), group incidence of Yersiniosis in the organized groups, mobility of genes of a virulence and change of pathogenic properties of Yersinia from strain to strain cause need of carrying out microbiological monitoring with a predictive component in new social and biological conditions.

Monitoring of polar ecosystems is one of the most important areas of research in the use of Arctic territories in economic activities. An important place in such work is occupied by biomedical research aimed at identifying the risks of the occurrence of foci of infectious diseases in the areas of polar settlements.The purpose: to develop an algorithm for microbiological monitoring in the Arctic region.Materials and methods: classical bacteriological, mycological research, molecular-genetic, MALDI-TOF mass spectrometric analysis, phenotypic methods for determining antibiotic resistance, methods of mathematical data processing.Results and their discussion. The paper considers the scientific and methodological principles and the main stages of microbiota monitoring in the areas of polar settlements. The results of the study of samples from several territories along the Northern Sea Route are presented. The main habitats where potentially dangerous microorganisms should be detected are indicated. The role of anthropogenic invasion in the formation of Arctic microbiocenoses is noted. The trends of increasing the number and diversity of pathogenic microorganisms, both in the natural biocenoses of the Arctic and in the areas of polar settlements, are discussed. The necessity of microbiological monitoring as an integral part of epidemiological monitoring in the areas of Arctic settlements along the Northern Sea Route is substantiated.

BACKGROUND: Reactions of human cardiovascular system to complex dynamic postural loads were under investigation by previous authors. Individual limiting mode of postural loads, i.e. alternating negative-positive periodic changes of body position angle on tilting table with regard to clinostatic position, was defined. It was demonstrated that application of oscillatory passive dynamic postural loads can cause certain hemodynamic reactions, which expression depend on postural loads dynamic characteristics and subjects primary state. AIM: Aim of the study is to develop comprehensive methodology (practice) that explores regulation mechanisms of cardiovascular, respiratory, central and autonomic nervous systems and their reactions to physiological strains with assigned properties (intensity, direction, periodicity and duration of postural loads). MATERIALS AND METHODS: 30 young healthy participants took part in the study. Physiological indicators were registered in dynamic mode synchronously with trajectory of participants motion. This study implemented common statistical methods as much as original means of analysis by integrating theory of dynamic systems. RESULTS: Evaluation of synchronously registered physiological indicators by means of instrumental and software application, in particular, postural loads protocols of various intensity and motion direction, showed that oscillatory passive dynamic postural mode allows considerable improvements in overall blood circulation and gas exchange in the lungs. These changes constitute in a rise of systemic and local blood flow without significant shift of arterial pressure, increased frequency of heartbeats and respiratory rate. CONCLUSIONS: Continuous monitoring of participants condition during complex postural loads give an opportunity for studying a set of physiological reactions and has a future implication in scientifically approved recommendations that describe practical use of postural loads as a correction technology for human health state and training.