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The objective of the present investigation was to improve dissolution characteristics of febuxostat, a BCS class-II drug by using microsponge drug delivery system. Febuxostat loaded microsponges prepared by using quasi emulsion solvent diffusion method. Optimized formulation was characterized by fourier transform infrared spectroscopy (FTIR), differential scanning calorimeter (DSC). Microsponge are design to deliver a pharmaceutical active ingredient efficiently at minimum dose and also to enhance stability, flexibility in formulation, reduce side effect and modify release profile. In-vitro dissolution profile was compared with the marketed product. Febuxostat loaded microsponges are promising approach for the controlled release drug delivery for Febuxostat and can be used for the development of suitable solid dosage form for commercialization. In-vitro dissolution results revealed that microsponge formulation containing 11:1 drug:polymer ratio has shown controlled release i.e. 97.31% up to 12 hrs which indicated that microsponges has shown better controlled release of drug, due to microporous nature of polymer generated in which the drug was entrapped. The microsponges drug delivery system formulated for the longer treatment of gout with hyperuricemia with increase stability.

The purpose of this study was to develop and optimize microemulsion containing agomelatine for intranasal delivery. Agomelatine, an antidepressant drug, has absolute bioavailability of only 5% due to high first pass metabolism. Agomelatine microemulsion and were prepared by titration method. Ternary phase diagram gave the microemulsion region and the concentration of oil; Smix and water were selected from ternary phase diagram. Based on solubility study, oleic acid, tween 80 and propylene glycol were selected as oil, surfactant and co surfactant respectively. Microemulsions were prepared using water titration method. 1:1% v/v ratio (Tween 80: Propylene glycol) was selected for formulation development. The prepared microemulsions were optimized optical transparency, viscosity measurement, phase separation, determination of pH, measurement of globule size, measurement of zeta potential, drug content, In vitro diffusion study, stability studies. The optimized batch was further characterized for optical transparency, viscosity measurement, phase separation, determination of pH, measurement of globule size, measurement of zeta potential, drug content, In vitro diffusion study, stability studies. Keywords: Depression, Intranasal, Microemulsions, Agomelatine

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Microsponge can be effectively incorporated into oral delivery of drugs using bio erodible polymer’s especially for colon specific delivery and also use for topical drug delivery system for retention of dosage form on skin and controlled release drug delivery system thus improving patient compliance by proving site specific drug delivery system and prolonging dosage intervals. The microsponge consists of myriad of interconnecting voids within non- collapsible structures with a large porous surface. The size of Micro sponges can be varied usually from 5-300 μm in diameter. The outer surface is typically porous, allowing the sustained flow of substances out of the sphere. Microsponge delivery system (MDS) can provide increased efficacy for topically active agents with enhanced safety, extended product stability, enhanced formulation flexibility , reduced side effects and improved aesthetic properties in an efficient and novel manner In addition these are non-mutagenic, non allergic, and non-toxic . The present review introduces Microsponge technology along with its synthesis, characterization, programmable parameters and release mechanism of MDS