Test beam measurements at the test beam facilities of DESY have been conducted to characterise the performance of the EUDET-type beam telescopes originally developed within the EUDET project. The beam telescopes are equipped with six sensor planes using MIMOSA 26 monolithic active pixel devices. A programmable Trigger Logic Unit provides trigger logic and time stamp information on particle passage. Both data acquisition framework and offline reconstruction software packages are available. User devices are easily integrable into the data acquisition framework via predefined interfaces. The biased residual distribution is studied as a function of the beam energy, plane spacing and sensor threshold. Its standard deviation at the two centre pixel planes using all six planes for tracking in a 6 GeV electron/positron-beam is measured to be (2.88 ± 0.08) μm. Iterative track fits using the formalism of General Broken Lines are performed to estimate the intrinsic resolution of the individual pixel planes. The mean intrinsic resolution over the six sensors used is found to be (3.24 ± 0.09) μm. With a 5 GeV electron/positron beam, the track resolution halfway between the two inner pixel planes using an equidistant plane spacing of 20 mm is estimated to (1.83 ± 0.03) μm assuming the measured intrinsic resolution. Towards lower beam energies the track resolution deteriorates due to increasing multiple scattering. Threshold studies show an optimal working point of the MIMOSA 26 sensors at a sensor threshold of between five and six times their RMS noise. Measurements at different plane spacings are used to calibrate the amount of multiple scattering in the material traversed and allow for corrections to the predicted angular scattering for electron beams.
44 Sc is a promising β + -emitter for molecular imaging with intermediate half-life of 4 h. Due to the chemical similarity of Sc 3+ to the Lu 3+ and Y 3+ cations, 44 Sc-DOTA bioconjugates are expected to demonstrate similar properties in vivo as the 177 Lu-and 90 Y-bioconjugates, what is important in planning the radionuclide therapy. 44 Sc can be obtained from the 44 Ti/ 44 Sc generator. An alternative method for 44 Sc production can be the irradiation of 44 Ca target at small cyclotrons. The aim of our work was to optimize the parameters of 44 CaCO 3 irradiation and to develop a simple procedure for 44 Sc separation from the calcium target. For optimization study, 44 CaCO 3 targets were irradiated by protons in the energy range of 5.6-17.5 MeV with 9 MeV being found to be the best energy for 44 Ca irradiations. A simple and fast separation procedure of 44 Sc from calcium target was developed using chelating resin Chelex 100. DOTATATE conjugate was successfully radiolabelled with high yield at elevated temperature using the produced 44 Sc. While 44 CaCO 3 is relatively expensive, the cost of 44 Sc-DOTATATE production can be reduced by target recovery. Due to low proton energy required to produce GBq activity level of 44 Sc, the availability of 44 Sc radioisotope could be enhanced to open new opportunities for applications in medical imaging.
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