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Two antisera reacting respectively with the brush border region of proximal renal tubules (BB) and Tamm‐Horsfall protein in distal tubules (TH) were employed for immunofluorescence studies of these antigens in 31 human kidney tumors of different types. All 15 cortical adenomas and 10 of 11 carcinomas contained the BB antigen but not the TH antigen. One anaplastic carcinoma studied lacked the BB antigen and together with one granular cell carcinoma showed weak TH antigenicity. The two Wilms' tumors examined contained both antigens. The findings provide additional evidence that the adenomas and carcinomas arise from proximal tubular epithelium and Wilms' tumors from more primitive metanephric cells.