Purpose. Evaluation of the volume of intravitreal injections in the treatment of neovascular form of age-related macular degeneration (nAMD) in an ophthalmological clinic. Material and methods. An analysis was made for 2021–2022. Aflibercept was used in all cases. The course began with 3 monthly loading injections with a further transition to the T&E treatment regimen. Results. A total of 467 nAMD patients received treatment in 2021. In their structure, 87 patients were primary, 380 people were repeated. The average number of injections was 6 during the first year in primary patients and 3 injections in repeat patients. Treatment was denied to 8 primary and 32 repeat patients for various reasons. In total, 522 injections were performed for primary patients and 1140 for repeated ones in 2021. The duration of therapy in all 380 repeat patients ranged from 2 to 9 years. 584 patients received nAMD treatment in 2022. One eye was treated in 492 people, both eyes were treated in 92 people. In their structure, 102 patients were primary, 482 people were repeated. The average number of injections was 6 during the first year in primary patients and 3 injections in repeat patients. Further treatment was denied to 4 primary and 42 repeat patients for various reasons in 2022. In total, 612 injections were performed in primary patients and 1,446 injections in repeat patients in 2022. In total, during the study period (two years), 1134 injections were performed in primary patients and 2586 injections in repeat patients. The number of «discharged» repeat patients was only 8.4 % in 2021 and 8.7 % in 2022. These figures objectively characterize the progressive increase in the total number of patients requiring anti-VEGF therapy for nAMD. It should also be noted that this analysis did not include patients with other pathologies requiring anti-VEGF therapy (diabetic macular edema, post-thrombotic retinopathy with macular edema, subretinal neovascular membrane). Conclusion. The obtained facts point to the need of search for more effective methods of treatment, what will probably allow to develop criteria for increasing the interval or stopping this type of therapy. Keywords: anti-VEGF therapy, intravitreal injections, aflibercept, age-related macular degeneration, volume of therapy

Background Short-segment transpedicular screw fixation (SSTSF) is the preferred treatment option for thoracolumbar burst fractures. Adding screws in the fractured body may be helpful in achieving and maintaining fracture reduction. However, the operative approach is disputed. Objective To compare clinical outcomes of transpedicular fixation with and without screws in the fractured vertebral body after isolated uncomplicated fractures at the thoracolumbar junction. Material and methods A retrospective cohort study enrolled 62 patients with Th11–L2 thoracolumbar burst fractures (AOSpine A3, A4) who underwent SSTSF with (n = 32) and without (n = 30) pedicle screws at the fracture level. Demographic data of the patients, operating time and blood loss were registered. Clinical evaluation using Visual analogue scale (VAS ) for pain, Oswestry Disability Index (ODI) to quantify disability and imaging parameters of segmental kyphosis, loss of correction, anterior vertebral body height (AVBH) at the fracture level, spinal canal stenosis (SCS) were measured preoperatively, at one week, 1 month, 6 and 12 months postoperatively. Results The patients of the two groups showed no statistically significant differences in the demographic data, VAS and ODI scores, measurements of kyphotic angle, AVBH, SCS preoperatively (p > 0.05). Screws at the fracture level did not affect the operating time and intraoperative blood loss relative to conventional no-screw group. Benefits with fracture screws were evident at 7 days (p < 0.01) measuring SCS, at 6 months (p < 0.01) and 12 (p < 0.01) months measuring kyphotic angle. There was better kyphosis correction (p < 0.01) and AVBH (p = 0.034) seen at 12 months after surgery. Conclusion Reinforcement of a broken vertebra with fracture-level screws has been shown to provide better stability of clinical and radiographic results as compared to those with conventional SSTSF.