PT. XYZ has various divisions, one of them is the R&D division. This division is responsible for research and innovation. The highest impact on accidents caused by a worker injured and bleeding around 14.29%. In addition, the highest potential hazards are raw material spill around 14.29%. Thus, the purpose of this paper is to identify the factors potentially that lead to the high potential hazards in the R&D division. In addition, it also formulates the alternative to decision-making strategies. The research method used the SWOT method and AHP to determine the priority to selecting strategies for reducing the potential for occupational hazards. This study used the questionnaires and distributed among five experts in the company. The result shows that the strategy of Weakness-Opportunity (WO) is the highest weight around 3.38. Then, the calculation by using the AHP method obtained that monitoring and evaluation of occupational health and safety through improvement of Work Instruction became the main priority is equal to 0.32. The AHP method also showed the consistency value of approximately 0.09. Therefore, further research is needed to evaluate the alternatives chosen.