Four alkaloids have been isolated from leaves of Ochrosia elliptica Labill. One has been shown to be identical with isoreserpiline. The other three, ellipticine, methoxyellipticine and elliptinine, have been characterized and certain features of their structures have been suggested.

Alkaloids of Lunasia amara Blanco 6209 tives appear to have a lower anesthetic efficiency (ratio of potency to toxicity) than the higher alkoxy derivatives. 2. Effect of varying the N-substituted group R': (a) branched chain groups were less potent and toxic than straight chain groups;(b) heterocyclic and aromatic amino groups had a lower anesthetic efficiency than the alkyl amino groups.Compounds 38, 40 and 41 proved to be more potent topically and less toxic than cocaine hydrochloride while compounds 13, 27, 29, 31, 32, 34, 35, 36, 40 and 41 were more potent on nerve block and infiltration anesthesia than procaine hydrochloride. The toxicity of this group ranged from equal to eight times as toxic as procaine hydrochloride. Several of these compounds when tried clinically in dental procedures were found to be as effective as procaine hydrochloride. The clinical evaluation is being continued and will be published elsewhere. ExperimentalThe o-and ^-anisóle and phenetoles were obtained from commercial sources.The ^-bromophenyl propyl ether and the m-and ^-bromophenyl butyl and isoamyl ethers were prepared by alkylating the bromophenol with the appropriate alkyl halide, with a method similar to that described for alkylating nitrophenols.61 %-Ethoxyphenyl-3-chloropropanol-2.-The Grignard reagent prepared from 42 g. (1.8 moles) of magnesium and (6) "Organic Syntheses,"

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The isolation of nine tertiary bases from Hunteria ebúrnea Pichón is described. Eburnamine (I), isoeburnamine (II), eburnamonine (III), and eburnamenine (IV) are the first members of a new class of pentacyclic indole alkaloids. A new variant of the yohimbinoid ring skeleton is found in burnamicine (VI). Of the remaining alkaloids the indolines pleiocarpine (V) and pleiocarpamine are known compounds, while burnamine, an indoline with an echitamine type ultraviolet absorption spectrum, and neburnamine, an indole, are new compounds.

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