Hyperglycemia that occurs in diabetic mellitus leads to glycation reactions in protein molecules and oxidative stress resulting in damage to cells and organs. Swallow nest believed society can lower blood glucose. The objective of the study was to analyze the potency of water swallow nest extract to prevent nephrophaty diabetic. The study used Post test-Only with Control Group Design, which consisted of 1 control group (K = aquadest) and 3 treatment groups (nest swallow nest dose 1, 10 and 100 mg / kg BW) each group consisted of 6 Rattus Norvegicius. Before treatment, means of glucose level rats have been 68 mg/DL, then rats were induced Streptozotocin in a dose of 40 mg / kg BW intraperitoneally. Day 7th after induction, rats had elevated glucose ± 102 - 108 mg / dL. Then the rats were given water extract nest swallow white for 28 days orally. All data were analyzed by Kruskall-Wallis test followed by Mann-Whitney test with 95% confidence level. The results of blood glucose levels in each group (K, P1, P2 and P3) were 111.0 vs 88.5 vs 86 vs 83 mg / dL (p = 0.004), pancreas H2O2 levels were 10.16 vs 9.20 vs 8.81 vs 7.27 (p=0,000), serum H2O2 levels were 17.35 vs 16.39 vs 15.01 vs 11.96 (p=0.044), renal methylglioxal levels were 242.55 vs 134.34 vs 67.12 vs 50.48% (p = 0,000) and renal AOPP levels were 1.17 vs 1.09 vs 1.05 vs 1.00 (p=0.000) respectively. The Mann-Whitney test showed a dose of 100 mg / kgBW has the greatest potential. In conclusion the swallow nest water extract has potential as an antidiabetic and prevent of renal’s damage.