Background and purpose: Flavonoids are a group of phytochemicals found abundantly in various plants. Scientific evidence has revealed that flavonoids display potential biological activities, including their ability to alleviate inflammation. This activity is closely related to their action in blocking the inflammatory cascade and inhibiting the production of pro-inflammatory factors. However, as flavonoids typically have poor bioavailability and pharmacokinetic profile, it is quite challenging to establish these compounds as a drug. Nevertheless, progressive advancements in drug delivery systems, particularly in nanotechnology, have shown promising approaches to overcome such challenges. Review approach: This narrative review provides an overview of scientific knowledge about the mechanism of action of flavonoids in the mitigation of inflammatory reaction prior to delivering a comprehensive discussion about the opportunity of the nanotechnology-based delivery system in the preparation of the flavonoid-based drug. Key results: Various studies conducted in silico, in vitro, in vivo, and clinical trials have deciphered that the anti-inflammatory activities of flavonoids are closely linked to their ability to modulate various biochemical mediators, enzymes, and signalling pathways involved in the inflammatory processes. This compound could be encapsulated in nanotechnology platforms to increase the solubility, bioavailability, and pharmacological activity of flavonoids as well as reduce the toxic effects of these compounds. Conclusion: in Summary, we conclude that flavonoids and their derivates have given promising results in their development as new anti-inflammatory drug candidates, especially if they formulate in nanoparticles.

Hyperglycemia that occurs in diabetic mellitus leads to glycation reactions in protein molecules and oxidative stress resulting in damage to cells and organs. Swallow nest believed society can lower blood glucose. The objective of the study was to analyze the potency of water swallow nest extract to prevent nephrophaty diabetic. The study used Post test-Only with Control Group Design, which consisted of 1 control group (K = aquadest) and 3 treatment groups (nest swallow nest dose 1, 10 and 100 mg / kg BW) each group consisted of 6 Rattus Norvegicius. Before treatment, means of glucose level rats have been 68 mg/DL, then rats were induced Streptozotocin in a dose of 40 mg / kg BW intraperitoneally. Day 7th after induction, rats had elevated glucose ± 102 - 108 mg / dL. Then the rats were given water extract nest swallow white for 28 days orally. All data were analyzed by Kruskall-Wallis test followed by Mann-Whitney test with 95% confidence level. The results of blood glucose levels in each group (K, P1, P2 and P3) were 111.0 vs 88.5 vs 86 vs 83 mg / dL (p = 0.004), pancreas H2O2 levels were 10.16 vs 9.20 vs 8.81 vs 7.27 (p=0,000), serum H2O2 levels were 17.35 vs 16.39 vs 15.01 vs 11.96 (p=0.044), renal methylglioxal levels were 242.55 vs 134.34 vs 67.12 vs 50.48% (p = 0,000) and renal AOPP levels were 1.17 vs 1.09 vs 1.05 vs 1.00 (p=0.000) respectively. The Mann-Whitney test showed a dose of 100 mg / kgBW has the greatest potential. In conclusion the swallow nest water extract has potential as an antidiabetic and prevent of renal’s damage.

Perilaku Hidup Bersih dan Sehat (PHBS) merupakan perilaku sehat yang dilakukan atas kesadaran, sehingga seseorang dapat menolong dirinya sendiri di bidang kesehatan. Penelitian ini mengambil 3 indikator dalam PHBS yaitu perilaku menggunakan jamban sehat, cuci tangan pakai sabun (CTPS) dan air mengalir, serta pemberian ASI (Air Susu Ibu) eksklusif. Data di Kota Palangka Raya menunjukkan persentase perilaku warga yang menggunakan jamban sehat sebesar 54%, perilaku cuci tangan pakai sabun 14%, dan perilaku pemberian ASI eksklusif 39,3%. Penelitian bertujuan menganalisis hubungan tingkat pengetahuan PHBS tatanan RT dengan PHBS (menggunakan jamban sehat, CTPS dan pemberian ASI eksklusif) warga  di bantaran Sungai Kahayan wilayah kerja Puskesmas Pahandut. Jenis penelitian observasional dengan pendekatan cross sectional. Sebanyak 95 responden yang memiliki balita di wilayah kerja Puskesmas Pahandut dipilih menggunakan teknik simple random sampling dan dianalisis dengan Chi Square (α=0,05). Sebanyak 54 responden memiliki tingkat pengetahuan PHBS yang baik, 67 responden berperilaku menggunakan jamban sehat dengan baik, 69 responden berperilaku CTPS dengan baik dan 53 responden memberikan ASI eksklusif . Semua p value=0.00. Terdapat hubungan tingkat pengetahuan PHBS tatanan RT dengan PHBS (menggunakan Jamban Sehat, CTPS dan Pemberian ASI eksklusif) warga di Bantaran Sungai Kahayan wilayah kerja Puskesmas Pahandut Palangka Raya Tahun 2016.

The Grade Point Average (GPA) as a measure of student performance in implementing the curriculum is expected to be correlated with the UKMPPD results to produce competent doctors with national standards. However, this is not in line with some who do not pass the UKMPPD at the Faculty of Medicine, University of Palangka Raya. This problem raises the question, can a medical student’s GPA ensure a fresh graduate doctor’s competency to pass UKMPPD? The research design was descriptive-analytic, with a cross-sectional design consisting of 132 students participating in UKMPPD as the first participants from May 2016 to November 2019. The data obtained were the results of preclinical and clinical GPA and UKMPPD. Data analysis using Pearson correlation test and Mann Whitney test. Statistical analysis showed that there was a significant relationship (p <0.001) between the preclinic GPA and the results of CBT (r = 0.642), OSCE (r = 0.329), and UKMPPD. Clinic GPA showed significant correlation (p <0.001) with CBT (r = 0.429), and UKMPD results (p = 0.001), but had no significant correlation (p = 0.167) with OSCE. These results indicate that the GPA of Preclinic and Clinic scores can be used as an indicator of learning outcomes to determine cognitive test results.

Manfaat dan potensi Potok (Etlingera elatior) untuk meningkatkan imunitas tubuh dapat digunakan sebagai alternatif sumber makanan kaya antioksidan. Manfaat potok untuk meningkatkan imunitas terutama di masa pandemi Covid-19, belum banyak diketahui oleh masyarakat Kalimantan Tengah khususnya di kota Palangka Raya. meningkatkan daya tahan tubuh, masyarakat lebih memilih mengkonsumsi vitamin dan herbal Kalimantan. Masyarakat Kereng Bangkirai sebagai wilayah binaan FK UPR belum mengetahui manfaat potok untuk kesehatan sehingga tidak banyak yang berminat menanam tanaman ini. Kegiatan Pengabdian kepada masyarakat oleh FK UPR akan melakukan program edukasi kesehatan dan manfaat potok untuk meningkatkan imunitas tubuh serta ragam cara pengolahannya serta budidaya bibit tanaman potok kepada masyarakat/ keluarga di Kereng Bangkirai. Kegiatan ini dilaksanakan dengan jumlah peserta sebanyak 20 orang yang berasal dari kelurahan Kereng Bangkirai. Hasil kegiatan didapatkan bahwa terjadi peningkatan pengetahuan masyarakat tentang kandungan antioksidan Potok bagi kesehatan dan peningkatan keterampilan dalam membudidayakan tanaman potok