This study does not support increased monocyte adhesion molecule expression or abnormal monocyte production of pro-inflammatory mediators as mechanisms for increased atherogenic risk in Type 2 diabetes. Cardioprotective actions of n-3 fatty acids may not be mediated through these mechanisms.

1PLCAT deficiency. Examination of the coding sequence of her Apo A1 gene revealed no mutations predicted to alter the Apo A1 protein. An in virro assay of Apo At-mediated cholesterol efflux, from dermal fibroblasts from the proband, showed a marked 91% reduction compared to control fibroblasts. This finding i s highly suggestive of a genetic defect in ABCAI, the major transmembrane active transporter regulating cholesterol efflux.There have been no reports of ABCAI defects from UK subjects to date.Measurement of cholesterol efflux from cultured dermal fibroblasts will be increasingly used as a screening tool to select individuals for further genetic analysis of the complex ABCAI gene.Introduction: Vascular disease states, such as hypertension, are associated with enhanced oxidative free radical (FR) pmdudion. NAD(P)H oxidase and xanthlne oxidase (XO) are two important sourms of vascular FR generation. We sougM to investigate t i d y . the expression and disttibbiion of these enzymes in human arteries and secondly, whether the vasoadlve hormone angiotensin I1 (ang II) migM affect their expression.