The Central Andes is a key global location to study the enigmatic relation between volcanism and plutonism because it has been the site of large ignim briteforming eruptions during the past several million years and currently hosts the world's largest zone of silicic partial melt in the form of the Alti plano Puna Magma (or Mush) Body (APMB) and the Southern Puna Magma Body (SPMB). In this themed issue, results from the recently completed PLUTONS project are synthesized. This project focused an interdisciplinary study on two regions of largescale surface uplift that have been found to represent ongoing movement of magmatic fluids in the middle to upper crust. The loca tions are Uturuncu in Bolivia near the center of the APMB and Lazufre on the Chile Argentina border, on the edge of the SPMB. These studies use a suite of geological, geochemical, geophysical (seismology, gravity, surface defor ma tion, and electromagnetic methods), petrological, and geomorphological techniques with numerical modeling to infer the subsurface distribution, quantity, and movements of magmatic fluids, as well as the past history of eruptions. Both Uturuncu and Lazufre show separate geophysical anomalies in the upper, middle, and lower crust (e.g., low seismic velocity, low resistiv ity, etc.) indicating multiple distinct reservoirs of magma and/or hydrothermal fluids with different physical properties. The characteristics of the geophysical anomalies differ somewhat depending on the technique used-reflecting the different sensitivity of each method to subsurface melt (or fluid) of different compositions, connectivity, and volatile content and highlight the need for integrated, multidisciplinary studies. While the PLUTONS project has led to significant progress, many unresolved issues remain and new questions have been raised.

The annual cost of eculizumab maintenance therapy in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic–uremic syndrome (aHUS) exceeds $300,000 per patient. A better understanding of eculizumab pharmacokinetics and subsequent individual dose adjustment could reduce this cost. We measured the trough eculizumab concentration in 9 patients with maintenance therapy (aHUS, n = 7; PNH, n = 2) and determined: 1) the intra- and inter-individual variability; 2) the influence of weight on eculizumab pharmacokinetics; and 3) the rate of elimination of eculizumab following discontinuation. A one-compartment model was developed to describe the pharmacokinetics of eculizumab and predicted complement activity by body weight. Trough eculizumab concentrations were >50 µg/mL in 9/9, >100 µg/mL in 8/9, and >300 µg/mL in 5/9 of patients. Intra-individual variability was low but eculizumab concentrations, closely correlated with patient weight (R2 = 0.66, p = 0.034), varied broadly (55 ± 12 to 733 ± 164 µg/mL). Pharmacokinetic modeling showed that the elimination half-life varied greatly, with an increase from 7.8 d in a patient weighing 100 kg to 19.5 d in a 40 kg patient. We predicted that infusions of 1200 mg could be spaced every 4 or 6 weeks in patients weighing <90 and <70 kg, respectively. In this pilot study, the current recommended use of a fixed eculizumab dose for maintenance therapy is associated with excessively high trough concentrations in many patients. Further prospective larger studies are now required to support an individualized schedule adjusted for patient weight and based on the observed trough serum eculizumab concentration.

A set of 14 teleseismic earthquakes was studied to determine how wave propagation was affected by a presumed magma body beneath Uturuncu volcano, Bolivia. Teleseisms are suitable for study because they are relatively long period, contain purely P waves, and have near-vertical incidence angles. The number of events is small but the events have good signal-to-noise ratios and very similar waveforms for each event so that reliable measurements could be made of arrival times and amplitudes. Attenuation of amplitudes occurs in a NW-SE trend beneath the volcano, 14 by 34 km (long axis NW-SE). Calculated values of the quality factor Qp are an average of 12.4, with extreme values as low as 1.8. These calculations are based on the assumption that the highest amplitude observed is the "true" amplitude, and all others have been attenuated. The average thickness of the anomaly is 10.2 km, and the center is ~20 km SE of the summit, within the area of surface uplift measured geodetically. Time delays of up to 0.8 s were also observed. The pattern of attenuation and relative time delays together showed four trends: fast and not attenuated (normal crust), slow and attenuated (partial melt), fast and attenuated (likely high fracture density), and slow but not attenuated (possible deep low Vp structure).Back azimuth differences of up to 60° were observed. In nearly all cases, azimuths were rotated into directions parallel to local rock fabric, suggesting that shallow crustal properties affected near-surface wave propagation. Overall results suggest partial melt as high as 10%-20% in a region of varying thickness, low Bouguer gravity and resistivity, high Vp/Vs, persistent seis micity, and overlapping a locus of recent uplift.

Aeromagnetic surveys over the Amargosa Desert, Nevada, have revealed the presence of several magnetic anomalies that have been interpreted to be caused by buried volcanoes; many of these anomalies have been confirmed by drilling. We present data collected from a high-resolution, ground-based magnetic survey over Anomaly B, the largest of these anomalies, that reveal details about a buried crater and its associated lava flow, not observed in the aeromagnetic surveys. These details provide insight into the nature of the eruption and volume of this buried volcano. Results from non-linear inversion demarcate a crater with a diameter of approximately 700 m and a base approximately 150 m below the ground surface. Coupled with well log data, the inversion results suggest a total volume for the Anomaly B crater area and associated lava flows of approximately 1.0 ± 0.4 km 3 , based on an estimated lava flow field area of 24 km 2 and a lava thickness of 42 ± 15 m. A workflow is presented for processing such large ground-based magnetic data sets with attendant GPS data, filtering these data and constructing maps and models using the provided PERL scripts.