of tubal occlusion in women with infertility, analysing studies that used laparoscopic tubal chromoperturbation dye test as the reference standard. Methods: Studies assessing 2D and 3D/4D HyCoSy for the assessment of tubal occlusion in women with infertility from January 1990 to April 2019 were searched using Medline and Web of Science databases by three authors, using the terms: ''hysterosalpingocontrast-sonography'', ''sonohysterosalpingography'', ''HyCoSy'', ''HyFoSy'', ''three-dimensional'', ''four-dimensional'', ''ultrasound'', ''tubal patency'' and ''tubal occlusion''. Quality was assessed using QUADAS-2 tool. Results: 30 articles were included: 21 studies used 2D HyCoSy to assess tubal occlusion, six used 3D/4D HyCoSy, one study used both techniques but in different set of patients and two used both techniques in the same patients. The risk of bias for most studies was low as assessed in QUADAS-2, except for patient selection domain. Overall, pooled estimated sensitivity and specificity of 2D HyCosy were 86% (95% CI = 80%-91%) and 94% (95% CI = 90%-96%), respectively. These figures were 95% (95% CI = 89%-98%) and 89% (95% CI = 82%-94%) for 3D/4D HyCoSy. High heterogeneity was found for both sensitivity and for specificity among studies. No statistical differences were found between methods (p = 0.13). Conclusions: We concluded that 2D HyCoSy has a similar diagnostic performance than 3D/4D HyCoSy. VP64.07 Is I-shaped uterus more common in patients with hyperandrogenism?

index (FI) and vascular flow index (VFI) of the fibroid, the vascular capsule and of its highest vascular area, using both manual and automatic contour modes. The intraclass correlation coefficient and discriminating values were calculated. The correlation between VI and volume was studied using Kendall's Tau test. Results: In the manual contour mode, the VI of the fibroid and of the vascular capsule had the highest interobserver agreement (ICC 0.89 and 0.87, respectively). Both parameters seem to have good discriminating values, given the large range of these parameters between different fibroids, independent of their volume. The vascularity of the fibroid and capsule were related. VI was not related to the volume of the fibroid. Conclusions: VI assessed using 3D PDUS is a reproducible parameter in the assessment of fibroid vascularization with discriminating abilities. Additional studies are needed to further evaluate validity and its clinical relevance.Supporting information can be found in the online version of this abstract Objectives: To assess user satisfaction with the Clinical Data Miner (CDM) software, used for collecting data for the International Endometrial Tumor Analysis (IETA) studies. Methods: We created an anonymous survey on http://www. surveymonkey.com. It first measures agreement, on a scale of zero to ten, with statements regarding user satisfaction. A second part quantifies the frequency of issues experienced by users.We sent the survey to users who had submitted at least 10 patient entries to the IETA studies, or who previously participated in an inter-rater agreement study organized using CDM. Selected participants thus had a certain level of CDM experience, ensuring meaningful results. Results: Of 42 selected users, 28 responded (66.7% response rate). User-friendliness of CDM's Visual Analogue Scale obtained the lowest average agreement (8.1), while the clarifying nature of the pictograms integrated in the user interface obtained the highest (9.4). CDM's user-friendliness was rated at 8.6. Most users (78.6%) experienced issues with CDM less than 5% of the time. Comprehensive results are available from https://www. surveymonkey.com/results/SM-QDYK9B7. Conclusions: CDM user satisfaction is very high. Most users experience relatively few issues. Users particularly like the integration of pictograms in CDM's user interface, and all responders would consider using CDM for their own studies.Supporting information can be found in the online version of this abstract Objectives: Abnormal Uterine Bleeding (AUB) above the age of 40 is a common complaint in gynecology. Endometrial Office Biopsy (EOB) is the primary method used to detect endometrial pathology. The objective of this study is to evaluate the effectiveness of three-Dimensional Saline Infusion Sonohysterography Guided Biopsy (3D SISHGB), as compared with EOB in diagnosing endometrial pathologies, (histological and anatomical) among peri-menopausal and post-menopausal women with abnormal uterine bleeding. Methods: It is an interventional ...

ВведениеСравнительный анализ динамики роста болезней цивили-зации за последнее столетие свидетельствует о том, что она характерна в основном для тех стран, население которых на-ходится под перманентным воздействием различных экстре-мальных факторов среды и развивающегося при этом психо-эмоционального стресса. К числу таких стран, являющихся удобной моделью для проведения широкомасштабных иссле-дований в этом направлении, относится Армения, население которой на протяжении 25 лет постперестроечного периода находится в состоянии психоэмоционального напряжения, связанного с последствиями катастрофического землетрясе-ния, продолжающегося военного противостояния, блокады, миграции населения и семейных катастроф. Беременные жен-щины являются наиболее уязвимой частью социума, испыты-вающего психоэмоциональный стресс [4, 12,16], последствия которого отражаются на организме не только матери, но и пло-да [8,9, 15].Несмотря на интенсивные исследования, проводимые в этом направлении, остаются малоизученными вопросы функциони-рования различных систем матери и плода и, в частности, осо-бенности кровообращения в системе мать-плод у беременных, переносящих стресс. Причем результаты проведенных в этом направлении исследований неоднозначны. В отличие от боль-шинства исследователей, обнаруживших в условиях стресса беременных нарушения в деятельности фетоплацентарного комплекса [22], некоторые [10] не находят изменений.В проведенных нами ранее исследованиях [3] показана взаимосвязь между состоянием реактивной и личностной тре-вожности у беременных и высокими индексами резистентно-сти в маточных артериях, несущих кровь к плоду.Исходя из вышеизложенного, целью настоящего исследо-вания явилась оценка кровотока в артерии пуповины, нисхо-дящей аорте и средней мозговой артерии плода беременных, переносящих психоэмоциональный стресс. МетодикаИсследовано 70 беременных женщин во второй половине беременности, на сроке 24-38 недель. Оценка уровня личност-ной (ЛТ) и реактивной тревожности (РТ) беременных прово-дилась с помощью опросника Спилбергера [21]. Итоговые показатели оценивались в баллах и соответствовали низкому (20-30), умеренному (31-45), высокому уровням (46-80).Исследование плодового кровотока проводилось с помо-щью ультразвукового аппарата «Shimadzu SDU 2200XPlus», снабженного блоком энергетического и цветного доплеров-ского картирования, с датчиком 3,5 МГц. Проводилась реги-страция кривых скоростей кровотока (КСК) в артерии пупо- Статистическая обработка данных прово-дилась с помощью компьютерной программы SPSS.Полученные результаты исследований подвер-гнуты статистической обработке с оценкой досто-верности по Стьюденту. Результаты исследованийНа основании анализа и оценки состояния тревожности по шкале Спилбергера беременные были распределены на 2 группы.I группа (контрольная) -20 женщин с физио-логическим течением беременности, в анамнезе которых во время беременности не было стрес-совых ситуаций, с низким уровнем личностной и реактивной тревожности.II группа (основная) -50 женщин, у которых в течение беременности были стрессовы...

We report two cases of ovarian teratoma, the immature and mature, demonstrating similar, high risk of malignancy sonographic features.Case 1: A 21-year-old woman was referred due to recurrent lower abdominal pain and right ovarian mass with CA-125 of 34.3 U/ml. Transabdominal and transvaginal sonography demonstrated a right ovarian multilocular-solid mass measuring 14x11x9cm. Irregular internal solid components reaching 5 cm in maximal dimension were observed on the posterior wall. The solid tissue was nonhomogenous with dispersed calcifications causing acoustic shadows. The liquid content was of low-level echogenicity. Few wide septa were depicted. The colour Doppler imaging showed intense vascular signals within the solid components and septa. The external borders of the tumour were regular. There was a positive sliding sign without tenderness. No normal ovarian tissue could be demonstrated. There were no ascites or signs of extra-ovarian metastases. The uterus and the left ovary were normal. According to IOTA ADENEX assessment, the risk of malignancy was 21%.Case 2: A 12-year-old girl was referred due to fever of unknown origin, and pelvic mass was discovered during the evaluation. The patient denied abdominal pain. Transabdominal and transrectal sonography demonstrated a right unilocular-solid ovarian mass measuring 9x8x7cm. The sonographic features of this mass were similar to those of Case 1, including intense vascular signals within the solid component on colour Doppler. IOTA ADENEX assessment revealed the risk of malignancy of 33%.Both patients underwent surgical excision of the masses. The histopathology revealed an immature cystic teratoma in Case 1 and a mature teratoma in Case 2.Our cases demonstrate that predicting immature teratoma using IOTA criteria is difficult; apparently ''malignant'' sonographic features can lead to false positive diagnosis.

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