Summary. An anatomical analysis of the innervation of murine femora revealed intimate association of haemopoietic and stromal cells with nerve fibres. The mechanical denervation of these femora resulted in significant mobilization of cells into the peripheral blood within 24 h. There was a decrease in femoral cellularity and analysis of the type of cells mobilized also revealed that there was an increase in progenitor cells in the peripheral blood. In non-splenectomized mice these progenitor cells were quickly cleared from the circulation. Chemical sympathectomy of mice with 6-hydroxydopamine resulted in decreased bone marrow cellularity without a change in bone marrow or peripheral blood progenitor cell numbers, nor the sustained rise in peripheral leucocytes observed with whole nerve denervation. These observations argue for selective control of mobilization by the nervous system and also indicate possible control of proliferation within the bone marrow. We conclude that the innervation has an important role in the maintenance of the blood-marrow interface, control of peripheral blood cell numbers, and mobilization of colony forming cells into the periphery.

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Because few prospective studies have addressed this issue, this study examined the relation between DM type 2 and leukocyte count, ESR, BMI, BP. Total and differential WBC count, ESR. BMI and blood pressure for 250 participants: 91 men and 159 women. Among 91 men there are 62 diabetic, and among 159 female subjects, 110 develop diabetes were measured. All using data were collected from diabetic Hospital. In the present work a graded association between higher WBC and diabetes mellitus type 2 was observed after adjusting for age, sex. ESR, BMI, and BP were also significantly associated (P < 0.05) with DM type 2. Smoking status has no real effect in the present data. These finding are consistent with the hypothesis that an activation of leukopoiesis may play a role in pathogenesis of DM type 2 and the inflammation is a dependent risk factor for diabetes. Additional studies are needed to determine whether circulating levels of inflammatory markers are associated with increased risk of incident diabetes.