Introduction: There is a significant association between psychiatric diseases and esophageal disorders. The upper esophageal sphincter (UES) function may be affected by psychiatric diseases. This study aims to evaluate the correlation between psychiatric symptoms (anxiety and depression) and UES pressure. Methods: We retrospectively reviewed data from 200 adult patients (median age 41 (34-53) years; 47% males). All patients underwent high-resolution esophageal manometry and ambulatory pH monitoring. UES basal pressure (UESP) was measured at the beginning of the test at the point of maximum pressure as an average of a period of 20 seconds after a period of adaptation. Hospital Anxiety and Depression Scale (HADS) was used to evaluate the presence of anxiety and depressive symptoms. Results: Median UESP was 80 (56-108) mmHg. There were 53 (26%) hypotonic (51% female, median age 43 (34-51) years), 100 (50%) normotonic (53% female, median age 42 (35-53) years) and 47 (23%) hypertonic (53% female, median age 38 (32-52) years) UES. There was no difference in HADS scores among groups. There was no correlation between UESP and HADS scores Conclusion: UESP does not correlate with minor psychiatric disorders.