The use of 3D scaffolds based on mesoporous bioactive glasses (MBG) enhanced with therapeutic ions, biomolecules and cells is emerging as a strategy to improve bone healing. In this paper, the osteogenic capability of ZnO-enriched MBG scaffolds loaded or not with osteostatin (OST) and human mesenchymal stem cells (MSC) was evaluated after implantation in New Zealand rabbits. Cylindrical meso-macroporous scaffolds with composition (mol %) 82.2SiO 2-10.3CaO-3.3P 2 O 5-4.2ZnO (4ZN) were obtained by rapid prototyping and then, coated with gelatin for easy handling and potentiating the release of inorganic ions and OST. Bone defects (7.5 mm diameter, 12 mm depth) were drilled in the distal femoral epiphysis and filled with 4ZN, 4ZN + MSC, 4ZN + OST or 4ZN + MSC + OST materials to evaluate and compare their osteogenic features. Rabbits were sacrificed at 3 months extracting the distal third of bone specimens for necropsy, histological, and microtomography (µCT) evaluations. Systems investigated exhibited bone regeneration capability. Thus, trabecular bone volume density (BV/TV) values obtained from µCT showed that the good bone healing capability of 4ZN was significantly improved by the scaffolds coated with OST and MSC. Our findings in vivo suggest the interest of these MBG complete systems to improve bone repair in the clinical practice.

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PurposeMetaphyseal fixation with porous titanium sleeves in revision knee surgery provides mechanical support to the implant, promotes biological fixation, and has shown satisfactory short‐ and mid‐term results. Cement is commonly used to fix the tibial tray to the epiphyseal area. The objective of this study is to determine whether cement should be used to achieve fixation of the tibial tray with the hypothesis that metaphyseal sleeves would provide enough axial and rotational stability making cementation unnecessary. Material and methodsProspective study of 60 patients undergoing knee replacement surgery with metaphyseal sleeves in type 2B defects in femur and tibia. Patients were divided into two groups according to the use of cement on the tibial component. Analysis included the American Knee Society Score (KSS) knee and functional scales, the Western Ontario and McMaster Universities (WOMAC) index, the Short Form 12 (SF‐12) health survey, and radiographic assessment with a maximum follow‐up of 5 years. ResultsNo statistically significant differences were found between the two groups in any of the parameters assessed. ConclusionMetaphyseal sleeves showed a 100% survivorship at five years of followup. There were no differences in clinical and radiographic outcomes at five years of follow‐up depending on whether or not cement was used for tibial platform fixation. Cementation of the tibial tray would therefore not be required to achieve satisfactory mid‐term results. Level of evidenceLevel II: prospective cohort study. Therapeutic.

<p>OBJETIVO: Evaluar la relación entre la incidencia de complicaciones y los resultados clínico-funcionales, tras el tratamiento de las fracturas de húmero proximal mediante osteosíntesis con placa bloqueada.</p><p>MATERIAL Y MÉTODO: Nuestro estudio revisa 47 pacientes intervenidos mediante osteosíntesis con placa en un periodo de 5 años. Presentamos los resultados clínico-funcionales con las escalas de Constant-Murley y Quick Dash, y con un análisis cinemático. Análisis estadístico de las relaciones complicación-resultados funcionales y reintervención-resultados funcionales.</p><p>RESULTADOS: Al final del seguimiento, fueron recogidos un total de 47 pacientes, con una edad media de 74,85 años. 11 pacientes (23,4%) tuvieron complicaciones, de los cuales 6 pacientes (12,7%) precisaron ser reintervenidos. La aparición de complicaciones se asoció a una pérdida de 65,41º de flexión, 14,49º de extensión, 36,71º de abducción, 8,84º de aducción, 5,47º de rotación externa y 30,82º de rotación interna. Además, se encontró relación estadísticamente significativa entre el desarrollo de complicaciones y las escalas Constant-Murley y Quick Dash.</p><p>CONCLUSIÓN: Existe un porcentaje elevado de pacientes que desarrollan complicaciones tras RAFI con placa, los cuales ven disminuida su funcionalidad de forma notable. Nuestro estudio cuantifica de forma exacta ésta pérdida y, de esta manera, predice la situación funcional, según las eventuales complicaciones que puedan aparecer.</p>