Setting: A hospital fertility center in France. Patient(s): Data were collected on all embryo transfers conducted using the strategy between February 2014 and February 2020. Intervention(s): Anatomical characteristics that could cause DiT were identified by transvaginal ultrasound and the catheter was adapted accordingly. Transfer was guided by transvaginal ultrasound. After passage through the cervix, a rest period was introduced to allow any contractions to stop before embryo deposition in the uterus. Main Outcome Measure(s): The primary criterion was the percentage of pregnancies per transfer (P/T) after an easy transfer (EaT) or a DiT. The secondary criteria included the anatomical causes of DiT and the patients' levels of discomfort. Result(s): Of 2,046 transfers, 257 (12%) were DiTs: minor difficulties (n ¼ 152; 7.4%), major difficulties (n ¼ 96; 4.7%), very significant difficulties (n ¼ 7; 0.3%), or impossible (n ¼ 2; 0.1%). The most common causes of DiTs were endocervical crypts (54%), tortuous cervical canal (36%), and marked uterine anteversions (30%). Several causes were often responsible for DiTs. There was no statistically significant difference in the P/T between the EaTs (n ¼ 1,789, 41%) and all degrees of DiT (n ¼ 257, 37%). In addition, there was no statistically significant difference between the level of patient-reported discomfort in the EaT and DiT groups.
Conclusion(s):This study demonstrated that an adapted embryo transfer strategy, monitored by transvaginal ultrasound, led to similar pregnancy rates regardless of whether the transfer was easy or difficult. (Fertil Steril Rep Ò 2021;2:43-9. Ó2020 by American Society for Reproductive Medicine.
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