Shells are a waste of crab (Portunus pelagicus) and green mussels (Perna viridis) waste in Karangantu. That is a problem for the environment with a large number. One solution is to use it as a raw material for chitosan. This study aims to see the potential of crab shells and green mussel shells as well as raw materials for chitosan biomaterials. This research used shell waste of P. pelagicus and P. viridis (3 replications). The stages of the method of this research include the preparation of raw materials, manufacture of chitosan, and analysis product. Parameters measured in this study include yield, moisture, ash, degree of deacetylation, and viscosity. The results showed that the yield, ash, and viscosity of green mussels shells were higher than that of crab shells, but the moisture and degree of deacetylation were lower. These results indicate that crab shells are better than clam shells, although the yield is lower as a potential for making chitosan from waste in Karangantu.