The detection of influenza A virions with a nanoribbon detector (NR detector) has been demonstrated. Chips for the detector have been fabricated based on silicon-on-insulator nanoribbon structures (SOI nanoribbon chip), using a complementary metal-oxide-semiconductor (CMOS)-compatible technology—by means of gas-phase etching and standard optical photolithography. The surface of the SOI nanoribbon chip contains a matrix of 10 nanoribbon (NR) sensor elements. SOI nanoribbon chips of n-type conductance have been used for this study. For biospecific detection of target particles, antibodies against influenza virus have been covalently immobilized onto NRs. Influenza A virus detection was performed by real-time registration of the source-drain current through the NRs. The detection of the target viral particles was carried out in buffer solutions at the target particles concentration within the range from 107 to 103 viral particles per milliliter (VP/mL). The lowest detectable concentration of the target viral particles was 6 × 10−16 M (corresponding to 104 VP/mL). The use of solutions containing ~109 to 1010 VP/mL resulted in saturation of the sensor surface with the target virions. In the saturation mode, detection was impossible.

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Abstract. The study proposes the way of data organization to store the information obtained as the result of measurements of morphological structures of prostate gland preparations in the computer microscopy system. The proposed data structure provides fast access to object features in interactive analysis of preparation images during oncologic diagnostics of prostate gland diseases.

This article presents the main areas of application of atomic force microscopy in biology and medicine, describes the principle of an atomic force microscope and the main modes of its operation. The works and results of the leading laboratories in the stated topic are considered. There are a number of proposals for generalizing the considered results into a unified knowledge base on diseases and the general state of health of the human body.