Background: Despite decades of research, neurodegenerative disorders like Parkinson’s disease remain a leading cause of disability worldwide, due to the insufficient reduction of disease burden by available medications. Recently the benefits of dietary supplements like co-enzyme Q10 (CQ10) in neurodegenerative diseases have been reported. Aim: The protective effects of supplemental CQ10 and possible additive benefits of CQ10/levodopa-carbidopa (LD) in Chlorpromazine (CPZ)-induced Parkinsonism-like changes in mice were investigated. Methods: Male mice were assigned to ten groups of 30 mice each. Groups are: Vehicle control (fed standard diet (SD), and given intraperitoneal (ip) plus oral saline), LD group (fed SD, and given ip saline plus oral LD), two groups fed CQ10-supplemented diet (at 60 and 120 mg/kg of feed), and given ip plus oral saline, CPZ group (fed SD, and given ip CPZ plus oral saline), CPZ/LD group (fed SD, and given ip CPZ plus oral LD), two groups fed CQ10-supplemented diet (at 60 and 120 mg/kg of feed) and given ip CPZ plus oral saline, and another two groups fed CQ10-supplemented diet (at 60 and 120 mg/kg of feed) and given ip CPZ plus oral LD. Total duration of study was 21 days, and treatments were administered daily. Body weight and food intake were measured weekly while, neurobehavioural and biochemical tests were assessed at the end of the experimental period. Results: CQ10-supplementation was protective against CPZ-induced parkinsonism-like changes including, reduction in mortality, reversal of retardation of open-field behaviours and reduction of catalepsy, increase in dopamine levels and decreased oxidative stress. CQ10 also showed significant improvements in these parameters when co-administered with LD. CQ10 (in groups administered CPZ/CQ10 60 mg/kg of feed) showed greater benefit over LD on anxiety-related behaviours and also had additive benefits on working-memory. Conclusion: Dietary CQ10-supplementation was associated with demonstrable benefits in CPZ-induced Parkinsonism-like changes in mice.

The study examined the perception of agricultural students towards computer based testing (CBT) in Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria. Multistage sampling technique was used to select 108 agricultural students of 200level across all the departments in the Faculty of Agricultural Sciences. However, the respondents have different perception toward CBT as mode of assessment newly introduced by the University management. There is significant relationship between some of the selected personal characteristics the respondents (such as department {(x2=68.481); age (x2=64.389); mode of admission (x2=166.056) and basis for supporting CBT examination (x2=33.333)} and their perception of CBT mode of examination. The study therefore recommends that CBT mode of examination should be encouraged and this innovation should cut across all other level apart from 100 level students. The academic staff members of different department and faculties should encourage the spread of the innovation across the University at large and the university management and department involved in the CBT examination should come together and provide solution to some of the associated constraints with CBT examination in LAUTECH as this would encourage its full adoption and its usage in the various departments and the entire University at large. Keywords: Perception; Agricultural Training; Students; Computer Based Test.

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The study assesses the attitude of senior secondary school students towards agriculture as a profession in some selected secondary schools in Ogbomoso North Local Government Area of Oyo State. One hundred respondents were randomly selected from five senior secondary schools purposively selected due to their questionnaire. The data obtained were analyzed with the aid of frequency count, percentages and cumulative percentage while correlation analysis was used to test the hypothesis. The findings reveal the personal characteristic of the respondents sampled as well as their level of interest in agriculture as a profession. The statistical analysis performed on the respondents’ attitude towards agriculture as a profession revealed that there was significant relationship to the respondents’ gender, educational level father and mother’s occupation respectively while age and religion were statistically insignificant.