The goal of this report is to analyse the incidence of genital tumours in cattle referred to the Clinic between 2016 and 2019 and to describe the outcome after the surgical tumour resection. All cattle with a confirmed diagnosis of a genital tumour (n = 3) were included in the study. The breed, age, tumour localisation and type of treatment were considered. Telephone interviews were used to ask owners about the integration of the cows into the herd after discharge, the survival, the reason for leaving the herd, wound complications and tumour recurrence. Three genital tumours including a vaginal fibrosarcoma, vaginal leiomyosarcoma and luteoma were diagnosed. A tumour recurrence or metastasis did not occur. In conclusion, the tumour resection was successful in all three cases. To our knowledge, this is the first clinical description of a cow with a luteoma.