Bacterial resistance to antibiotics is a major therapeutic problem. Bacteria use the same mechanisms for developing resistance to antibiotics as they do for developing resistance to biocide compounds present in some cleaning and personal care products. Root-nodulation-cell division (RND) family efflux pumps are a common means of multidrug resistance, and induction of their expression can explain the observed cross-resistance found between antibiotics and biocides in laboratory strains. Hence, there is a relationship between the active chemicals used in household products, organic solvents and antibiotics. The widespread use of biocide-containing modern-day household products may promote the development of microbial resistance and, in particular, cross-resistance to antibiotics.

The aim: To improve epidemiological monitoring of pertussis by analyzing the disease morbidity during 1995-2017 in Ukraine, to make a prognosis. Materials and methods: Analysis of the pertussis morbidity during 1995-2017 using the data of the Ministry of Health of Ukraine. The cyclicity was determined by Fourier spectral analysis. The models of prognosis were constructed using polyharmonic regression and an exponential smoothing algorithm. Cartographic analysis and integrated indicators (multiyear index of the prevalence rate, mean square deviation, mean the multiyear pace of the gain in the prevalence rate) were used to determine the areas of risk. Summarized data were used to calculate the generalized coefficient. Results: The pertussis morbidity cycle has 5 years intervals in Ukraine. The prognosis is for increasing the pertussis morbidity from 4.91-5.54 to 5.48-7.06 per 100.000 people. The generalized coefficient was significantly higher in western part (83.3%) than in central (50.0%) and eastern (16.6%) parts. The study showed that population reproduction rates, natural population increase, and the proportion of people against vaccination were higher in the western part than in other parts of the country. Conclusions: The pertussis cyclicity depends on the internal mechanisms of interaction in the ecological system. There is a prognosis of worsening the epidemic situation of pertussis spreading. The risk area is the western part of Ukraine, which is characterized by active demographic processes and a greater number of people who are negative about vaccination.

Purpose : Comparative analysis of the physical development features and somatotype of girls and women involved in fitness. Material : The experiment involved 95 girls and women, divided into 2 groups. Group 1 - 48 girls (36.04 ± 0.19) years, Group 2 - 47 women (43.26 ± 0.22) years, (p <0.01). Participants practiced fitness 2-3 times a week. The duration of the training was 60 minutes. It was determined the body mass and body length, wrist circumference, waist and hips circumferences. The TANITA BC 587 analyzer was applied to determine muscle and fat mass, the specific weight of fat tissue, water content, percentage of visceral fat, basal metabolism value, bone mass mineralization. It was calculated the body mass index and the waist-to-hip ratio. The results were evaluated applying the Student's t-test (t) and Rosenbaum (Q) and Wilcoxon - Mann - Whitney (U) criteria. Results : There were no significant differences in body length and body mass. The girls confirmed a less value of hip circumference (t = 2.04, p <0.05) and a tendency to less waist circumference (t = 1.97, p <0.1) in comparison with group 2. The participants of group 2 had a larger wrist circumference (U = 891, p <0.05). According to this parameter, persons with asthenic body type prevailed among participants. Their specific weight was (56.25 ± 7.16)% of group 1 and (53.19 ± 7.28)% of group 2. It was confirmed less absolute body fat content in group 1 (t = 2.09, p <0.05). All participants were characterized by larger muscle mass. There were no differences in this parameter between groups. It was determined the high concentration of specific weight of fat tissue in comparison with age standards. The content of visceral fat was within the age norm. Its content was higher in group 2 (Q = 18, p <0.01). The basal metabolic value was larger in group 2 (Q = 17, p <0.01). The values of bone mass mineralization reflect the correspondence to the body mass of the participants. This parameter did not have significant differences in the groups. The body mass index value in group 1 was within the average interval. In group 2, this index was higher than the standard one. The body mass index in group 1 was significantly lower (t = 2.18, p <0.05). The participants with a body mass index above the norm were (35.42 ± 6.90)% of group 1 and (59.57 ± 7.16)% of group 2. The prevalence of waist-to-hip ratio above the norm was (54.17 ± 7.19)% 1 group and (59.57 ± 7.17)% 2 group, (p> 0.05). Conclusions : it was determined the proximity of the main anthropometric parameters (mass and body length). The girls have lower values of the hip circumference. Persons with asthenic body type prevailed among the participants. Analysis of the indices confirmed the high prevalence of overweight and high risk of developing metabolic syndrome. The application of bio-impedance method confirmed and clarified the results of anthropometric research. The participants demonstrated the increased content of subcutaneous and visceral fat, increasing with age. The water level in the body gradually decreases with age. This is considered as a reflection of age-related physiological changes in metabolism and should be considered in fitness training organizing. Studies have confirmed the informativeness and adequacy of the bio-impedance method.

Background: The significance of some infection sources, pathways of pathogen transmission and etiological structure of diarrhea infections (DI) have changed. Many issues of DI epidemiology are still insufficiently studied, which prevents the organisation of quality epidemiological surveillance and diseases control. Objectives: To study the DI epidemic situation (ES) in North- Eastern Ukraine and to identify the factors that determines the characteristics of epidemic process (EP). Material and Methods: The reports of Ministry of Health of Ukraine (1960- 2018) and Head Statistics Administration of Sumy Oblast (2001-2018) have been used. The biological properties of 40 strains of K. pneumoniae, 50 - S. aureus, 40 - E. cloacae recovered from the feces of patients with DI have been studied Results: It has been found that the EP of DI is characterized by a sharp decrease in the incidence of typhoid fever and shigellosis, increase in the incidence of salmonellosis and dominance of DI caused by other specified or unspecified pathogens (SDI and UDI) in the nosological structure (p<0.05). The incidence of DI caused by Klebsiella, Staphylococus, Enterobacters exceeds the incidence of salmonellosis, shigellosis, typhoid fever (p<0.05). Opportunistic pathogens (OP), which are pathogens of DI have antilysozyme activity and adhesion ability, which proves their pathogenic potential. The demographics indirectly affect the incidence of DI. Access to water supply, sewerage, hot water supply is correlates with the incidence of DI. Conclusion: The system of epidemiological surveillance over DI in Ukraine needs improvement by optimisation its information and analytical subsystems aimed at objective epidemiological diagnostics and ES forecasting. Bangladesh Journal of Medical Science Vol.19(3) 2020 p.420-426

Background: The infectious diseases of viral etiology with airborne transmission generally dominate in the structure of infectious incidence. Objective: To determine incidence of viral infections with airborne transmission in the north-eastern region of Ukraine, to research the impact of social and natural factors on the intensity of epidemic process. Methods: In order to determine the current epidemiological peculiarities of infections with airborne transmission in the north-eastern region of Ukraine, a retrospective and operative analysis of the incidence, reports of vaccination of decreed child population in 2009‒2019, demographic and natural indicators. Results: Trends in the incidence of influenza were characterized by chaotic nature and disorder, acute respiratory viral infections ‒ high intensity and monotony. Significant correlations were established between the incidence of influenza and number and density of the population, the incidence of acute respiratory viral infections and the coefficient of migration population movement. Direct strong correlations were found between social factors and trends in the incidence of rubella and mumps. Coronavirus infection COVID–19 has become the problem for health care facilities in Sumy oblast. Conclusion: Quantitative and qualitative characteristics of the epidemic process of infections of viral etiology with airborne transmission have changed, which requires new approaches to organization of the system of epidemiological surveillance. Bangladesh Journal of Medical Science Vol. 21 No. 03 July’22 Page: 610-619