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ÀÍÀËÈÇ ÏÐÈ×ÈÍ ÐÀÇÂÈÒÈß ÃÅÌÎÔÒÀËÜÌÀ ÏÎÑËÅ ÂÈÒÐÝÊÒÎÌÈÈ Ó ÁÎËÜÍÛÕ ÏÐÎËÈÔÅÐÀÒÈÂÍÎÉ ÄÈÀÁÅÒÈ×ÅÑÊÎÉ ÐÅÒÈÍÎÏÀÒÈÅÉ Ä. Í. Ïîãîðåëûé, àñïèðàíò, À. À. Ïóòèåíêî, ñò. í. ñîòð., ä. ìåä. í. ÃÓ «Èíñòèòóò ãëàçíûõ áîëåçíåé è òêàíåâîé òåðàïèè èì. Â. Ï. Ôèëàòîâà ÍÀÌÍ Óêðàèíû» Ïðîâåäåíî ïîð³âíÿëüíèé àíàë³ç äâîõ ãðóï õâîðèõ íà ïðîë³ôåðàòèâíó ä³àáåòè÷íó ðåòèíîïàò³þ, îñíîâíî¿ -68 îñ³á (68 î÷åé), ó ÿêèõ ï³ñëÿ â³òðåêòî쳿 ïðîòÿãîì 2-2,5 ì³ñÿö³â çáåð³ãàâñÿ ãåìîôòàëüì, òà êîíòðîëüíî¿ -75 õâîðèõ (75 î÷åé) ç ïîâíîþ ïðîçîð³ñòþ â³òðåàëüíîãî âì³ñòó â òîìó ae òåðì³í³ ï³ñëÿ âòðó÷àííÿ Äîñë³äaeåííÿ ïîêàçàëè, ùî ãåìîôòàëüì äîñòîâ³ðíî ÷àñò³øå ðîçâèâàâñÿ ïðè: ä³àáåò³ I òèïó ( 2 = 7,46, ð = 0,006), ã³ïîãë³êå쳿, ïåðåâàaeíî â í³÷íèé ÷àñ ( 2 = 8,48, ð = 0,004), ï³äâèùåíí³ àðòåð³àëüíîãî òèñêó ( 2 = 7, 40, ð = 0,007), íàÿâíîñò³ äî îïåðàö³¿ òîòàëüíîãî ãåìîôòàëüìà ( 2 = 5,86, ð = 0,016), ðåöèäèâóâàíí³ ãåìîôòàëüìà ïðîòÿãîì 6 ì³ñÿö³â äî îïåðàö³¿ ( 2 = 6,68, ð = 0,009), ðîçâèòêó ³íòðà-îïåðàö³éíèõ êðîâîòå÷ ( 2 = 7,67, ð = 0,006), ðîçâèòêó ã³ôåìè ( 2 = 4,71; ð = 0,03) ç íåîáõ³äí³ñòþ ¿¿ ïðîìèâàííÿ â ðàíí³ òåðì³íè ï³ñëÿ îïåðàö³¿ ( 2 = 4,95, ð = 0,026), à òàêîae ïðè ðîçâèòêó åêñóäàòèâíî¿ ðåàêö³¿ â ðàííüîìó ï³ñëÿîïåðàö³éíîìó ïåð³îä³ ( 2 = 5,76; ð = 0,016), ùî ñóïðîâîäaeóºòüñÿ ï³äâèùåííÿì îôòàëüìîòîíóñà ( 2 = 9,35, ð = 0,002). Êëþ÷åâûå ñëîâà: ïðîëèôåðàòèâíàÿ äèàáåòè÷åñêàÿ ðåòèíîïàòèÿ, âèòðýêòîìèÿ, ãåìîôòàëüìÊëþ÷îâ³ ñëîâà: ïðîë³ôåðàòèâíà ä³àáåòè÷íà ðåòèíîïàò³ÿ, â³òðåêòîì³ÿ, ãåìîôòàëüì

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Aim. To study vascular endothelial growth factor (VEGF), tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β) and interleukin-1 receptor antagonist (IL-1RA) blood and vitreous humor levels in patients with proliferative diabetic retinopathy (PDRP) and post-vitrectomy hemophthalmia. Methods. 82 patients (82 eyes) with PDRP and post-vitrectomy hemophthalmia present 2 months (from 55 to 78 days) after performed vitrectomy were examined. Results. In patients with proliferative diabetic retinopathy (PDRP) and post-vitrectomy hemophthalmia VEGF blood level remained normal in 92.7% of cases, TNF-α blood level was normal at all times, blood level of IL-1β was within normal ranges in 93.8% of cases, and IL-1RA blood level was decreased in 74.4% of cases. Vitreous humor level was above normal ranges for VEGF - in 84% of cases, for TNF-α - in 9,9% of cases, IL-1β vitreous humor level was within reference ranges at all times, and IL-1RA vitreous humor level was decreased in 84.1% of cases. Conclusion. The gained data indicates further vascular proliferation in the eye cavity as a leading factor for hemorrhage relapses, despite the vitrectomy performed.