Blood and vitreous humor cytokine profile in patients with proliferative diabetic retinopathy and post-vitrectomy hemophthalmia

Abstract

Aim. To study vascular endothelial growth factor (VEGF), tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β) and interleukin-1 receptor antagonist (IL-1RA) blood and vitreous humor levels in patients with proliferative diabetic retinopathy (PDRP) and post-vitrectomy hemophthalmia. Methods. 82 patients (82 eyes) with PDRP and post-vitrectomy hemophthalmia present 2 months (from 55 to 78 days) after performed vitrectomy were examined. Results. In patients with proliferative diabetic retinopathy (PDRP) and post-vitrectomy hemophthalmia VEGF blood level remained normal in 92.7% of cases, TNF-α blood level was normal at all times, blood level of IL-1β was within normal ranges in 93.8% of cases, and IL-1RA blood level was decreased in 74.4% of cases. Vitreous humor level was above normal ranges for VEGF - in 84% of cases, for TNF-α - in 9,9% of cases, IL-1β vitreous humor level was within reference ranges at all times, and IL-1RA vitreous humor level was decreased in 84.1% of cases. Conclusion. The gained data indicates further vascular proliferation in the eye cavity as a leading factor for hemorrhage relapses, despite the vitrectomy performed.