A two-stage polylactide modification was performed in the supercritical carbon dioxide medium using the urethane formation reaction. The modification resulted in the synthesis of polymerizable methacrylate derivatives of polylactide for application in the spatial 3D structuring by laser stereolithography. The use of the supercritical carbon dioxide medium allowed us to obtain for the first time polymerizable oligomer-polymer systems in the form of dry powders convenient for further application in the preparation of polymer compositions for photocuring. The photocuring of the modified polymers was performed by laser stereolithography and two-photon crosslinking. Using nanoindentation, we found that Young’s modulus of the cured compositions corresponded to the standard characteristics of implants applied in regenerative medicine. As shown by thermogravimetric analysis, the degree of crosslinking and, hence, the local stiffness of scaffolds were determined by the amount of the crosslinking agent and the photocuring regime. No cytotoxicity was observed for the structures.

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In this work, the biomedical applicability and physical properties of magnesium-based metallic glass/polycaprolactone (PCL) composites are explored. The composites were fabricated via mechanical alloying and subsequent coextrusion. The coextrusion process was carried out at a temperature near to the supercooled liquid region of the metallic glass and the viscous region of the polymer. The structures, as well as thermal and mechanical properties of the obtained samples were characterized, and in vivo investigations were undertaken. The composite samples possess acceptable thermal and mechanical properties. Tensile tests indicate the ability of the composites to withstand more than 100% deformation. In vivo studies reveal that the composites are biologically compatible and could be promising for biomedical applications.