The Lawu mountainside community uses local wisdom in its preservation of medicinal plants. The goal of this research is to describe the role of local wisdom in preserving and diversifying the use of medicinal plants. The research uses a qualitative method with an explorative approach to explore local wisdom and the optimization of medicinal plants. The research results show that the Lawu mountainside community, who use a wealth of local wisdom in the preservation and optimization of the diversification of medicinal plant use, supported by the potential of natural beauty, have managed to preserve and transfer this local wisdom to the younger generation and create a tourism site to attract visitors. This has had implications on economic and social cultural aspects. In the economic aspect, it has led to a development in the local economy, while in the social cultural aspect, it has brought about an internalization of ecological values in management of the natural environment.