Hypertension is categorized as the silent disease since the patients do not know that they have it before taking the blood pressure check-up. Hypertension which is not treated properly and prolonged can effect to stroke, heart attack, and main factor of chronicle kidney failure. The hypertension can non-pharmacology. The classical music and Qur'an Murottal therapies. to identify the effectiveness of classical music and Qur'an murottal on patients with hypertension in middle adulthood. the type of research is quasi experimental design with the method of two groups in pre and post test design. The sample of this research is 32 persons result shows the systolic score of p value is 0,005 (p<0,05), it means there is the meaningful difference, while the diastolic score of p value shows 0,287 (p>0,05), it means there is no meaningful difference. The drop mean of blood pressure in classical music therapy group is systolic s4,06 mmHg and diastolic 2,54 mmHg, while the Qur'an murottal therapy group is systolic 6,90 mmHg and 3,27 mmHg.: this research proves that the Qur'an murottal therapy is more effective in dropping the blood pressure than the classical music therapy.