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Diagnostic of pathogen in the human biological liquids by biochip technology is an intensively developed methodic now. The main and the most important part of biochip is the adsorbing layer. Adsorption properties of chalcogenide films to protein (rat monoclonal antibodies) were tested. The films were prepared by conventional thermal deposition technique and by pulsed laser deposition technique. Two methods were used for forming in the films the two-dimensional map of adsorbing places for probe testing. One is using photoresist properties of chalcogenide films; another is using photo-induced oxidation of chalcogenide films. It was shown Good selectivity of the developed structures to protein markers was shown.

The change of the rate of dissolution upon the exposure of bilayer As 39 S 61 /As 36 S 44 Se 20 films to light of wavelength 380 nm and more than 470 nm from the sulfo selenide layer side has been investigated. Although light of wavelength 380 nm is absorbed in the first layer, in the second layer photoinduced structural changes are observed, which are assumed to occur as a result of the diffusion of electron-hole pairs from the illuminated selenium containing layer to the nonexposed arsenic sulfide in contact. The excess charge carriers induce struc tural changes in the As 39 S 61 film that are registered as dissolution rate changes. The calculated value of the drift mobility of the slowest charge carriers (electrons) of 10 -11 cm 2 /(V s) is in agreement with the literature data. Studies of the Raman spectra of the films of interest confirmed that the diffusion of excess electrons and holes into the sulfide layer resulted in structural changes that manifested themselves in a decrease in the intensities and widths of the bands corresponding to vibrations of structural groups containing homopolar bonds.