We studied molecular mechanisms of immunoprotective effects of two dipeptides, AB-O and R-1, on cultured human and rat thymic cells. Both dipeptides were shown to increase the expression of lymphocyte differentiation marker CD5 in thymic cells. Dipeptide AB-O induced T-cells precursor differentiation towards CD4(+)T-helpers and its effect was weaker than that of dipeptide R-1. Dipeptide R-1 stimulates differentiation of CD5(+) cells to mature T-helpers and cytotoxic CD8(+) T cells and hence can be considered as a bioactive substance possessing immunomodulator and antiallergic activity.

Segment-specific characteristics of the reactions of pial arteries of different generations to intravenous injection of norepinephrine were studied under conditions of instrumental stabilization of systemic blood pressure in rats with blocked α- and β-adrenoceptors.

Differential characteristic of the reaction of pial arteries of various generations to intravenous administration of norepinephrine was obtained in experiments on rats under artificially stabilized systemic blood pressure.

Experiments on WKY and SHR rats showed that low-intensity laser irradiation reduced the tone of pial arterial vessels thereby potentiating the subsequent constrictor effect of norepinephrine. Irradiation in the red region of the spectrum produced a more pronounced effect in the blue region. The observed effects were less pronounced in SHR rats compared to normotensive WKY rats.

On the basis of the created robotic complex with a program for a survey with illustrations (by the type of whether there are similar forms of pathology) of major tumors, a portable USB microscope built into a flexible hose and the body of the complex for transmitting to the touch screen pathological changes in visible localizations (skin, oral cavity). The survey was conducted in 38 patients with a certain trajectory for men and women on the touch screen. The use of the robotic complex allowed patients to suspect tumors of the skin, oral cavity, thyroid gland, lymph node enlargement in 39.4%±1.7%, of which 53.4%±1.9 with further examination of cancer was confirmed, including 2 patients with melanoma and 4 basal cell carcinoma. In the presence of complaints from the stomach, heartburn or belching with a smell on an empty stomach, 17 patients underwent a “breathing test” (basal and with a load of urea) on the Helik-Scan of AMA LLC, built into the program of the robotic complex. The color change in the “breathing tubes” was scanned with fixation on the touch screen, 7 of them had Helicobacter pylori above 10 units with load. In 5 patients with FGS, metaplasia (MP-1 and MP-2) was established, in 2 gastric ulcer and one of them with malignancy. After examination of the patient and processing of the results with a robotic complex, recommendations for further tactics were sent via the confidential Internet to the doctor of the prevention Cabinet.