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Sometimes timely detection of asthma is difficult so as mild asthma is often underestimated. This point is of particular importance in adolescents due to medical expertise for future military service. Three hundred and sixty one young men aged 15 to 18 were referred to the Republic clinical immunology centre of Kazan from military registration offices to confirm the diagnosis of asthma. Asthma was diagnosed according to the algorithm included analysis of medical records, clinical examination, special allergologic tests, and challenge tests with inhaled allergen, histamine, hypertonic solution or physical exercise if necessary. The results of the combined examination have confirmed the diagnosis in 344 patients (95.3 %); 77.3 % of the asthmatic patients had mild asthma.

Background. Glucosaminylmuramyl dipeptide (likopid) is a selective NOD2 receptor agonist, its ability to activate phagocytes proves its use in infectious manifestations in asthma patients. Its influence on the adaptive immunity, was studied. The aim of the study was to evaluate the effectiveness of likopid in patients with atopic bronchial asthma and recurrent infections of the respiratory tract. Materials and methods. 44 patients with uncontrolled atopic bronchial asthma with recurrent respiratory tract infections were examined. Patients of group I received likopid 10 mg orally once a day during 10 days additionally to the complex therapy. Patients of group II received only complex therapy without likopid. The immune parameters, disease control parameters, frequency of exacerbations and spirography data in patients of two groups before the treatment and after 10 days, 1 and 3 months were assessed. Results. Both I and II group patients (91,6%) showed similar deviations of the immune status parameters in general, a depression of the functional activity of phagocytes was noted in 83,3% of cases. Patients of group I were characterized by the achievement of better asthma control in 1 month of treatment, while the frequency of asthma exacerbations required revision of therapy was lower in patients of group I than in patients of group II (8,3% and 45%, respectively, p

Primary immunodeficiency is a rare disease with a high medico-social significance. Objective: to characterize principal clinical syndromes in 35 patients from 12 to 37 years old with primary immunodeficiency associated with an abnormal antibody production. The infectious syndrome is the most significant syndrome, it was revealed in all the patients, in some cases it was combined with autoimmune, atopic and lymphoproliferative syndrome. Thus, there isthe need to inform physicians of variousspecialties about this pathology. Conflict of interest: The authors of this article confirmed the lack of conflict of interest and financial support, which should be reported.