Lung cancer (LC) is leading oncological pathology, posing a serious threat for patient’s lives.
Accordingly to World Health Organization (WHO) 2,1 million of new cases and 1,8 of deaths are
annually registered. It was accumulated a lot of information about significant influence of smoking on
increased risk of LC development. 80-90% of patients with LC are namely smokers. However at present
time it was registered increased level of mortality from this pathology among non-smoking patients [1].
LC formation in non-smoking individuals can occur due to environmental pollution by industrial and
household cancerogens and also because of molecular and genetical and cytogenetical dissimilarities.
Since LC development can be associated with anomalous immunological response, immune genes can
be considered as potential biological markers [2].
Objective: To assess the influence of polymorphic variants of innate immunity genes on LC
development in non-smoking patients.
Breast cancer (BC), with nearly 1.7 million incidence and 522,000 deaths (according to
GLOBOCAN statistics), is the most frequently occurring cancer in women. The etiology of BC is
multifactorial and has not been fully elucidated. However, genetic factors are known to increase or
decrease susceptibility to BC, suggesting that genetic polymorphisms play an important role in the
oncopathology.
Accordingly to these facts, the aim of our study was the analysis of polymorphic variants of
DNA repair genes ADPRT 2285 A>G rs113641 in BC patients and conditionally healthy women of
Kemerovo region.
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