Acinobacter baumanii is one of the pathogenic bacteria that has several antibiotic resistance. Streptomyces is a potential bacteria that can produce several antibiotics. Aim of this research were to determine chemical compound and analysis in silico extract of n butanol Streptomyces drozdowiczii. Streptomyces drozdowiczii showed the presence of 10 peaks identified as Cyclohexene, 1-Methoxy-1-buten-3-yne, Butanenitrite, n-Butyronitrite, 1-Pentane-3-yne-2-methyl, 3,3,5-Trimethylcyclohexylamine, 9-Borabicyclo (421) nonane-dimer and 3-Methyl-2-oxo-2-pyrane-6-carboxylic acid. Analisis in silico showed an interaction occurs between 5 compounds of Streptomyces that function as antimicrobial agents. The conclusion n butanol extract of S.drozdowiczii has a potential as new antibiotic against A. baumanii