Objectives: To find out the risk factors and their effects on mother and fetus in pregnancy with thrombocytopenia. Study Design: Cross sectional study. Setting: Department of Obstetrics and Gynaecology at Liaquat University Hospital Hyderabad. Period: Six months (1st July 2016 to 31st December 2016). Material and Methods: Total 96 patients with gestational age >24 weeks having platelet count below 150X109/L were included in the study. Patients admitted throughout patient clinic department of obstetrics & Gynecology at Liaqat University Hospital. Those patients having platelet count below 150X109/L were registered for study. Proforma filled which include Patients demographics details, gestational age, complete blood count (Having platelet count) other important investigations like coagulation profile (PT, APTT), Ultrasound and LFT noted in proforma SPSS version used for analysis. Descriptive statics were calculated frequency and percentages were drawn for the study. Results: Risk factors related to thrombocytopenia included PIH18 (18.8%), preeclampsia 14(14.6%), eclampsia 10(10.3%), HELLP Syndrome 6(6.3%), Viral Hepatitis 12(12.5%) and in 36(37.5%) no risk factors was found. Maternal complication were placental abruption21 (21.8%) post partam hemorrhage 14(14.6%). 7(7.3%) were transferred to ICU and 02(2.1%) maternal death was seen. Fetal outcome include low Apgar score of <6 in 17(17.7%), low birth weight 16(16.7%) and NICU admission 11(11.5%). Conclusion: Thrombocytopenia is a common finding in pregnancy careful diagnosis is important to distinguish serious causes from mild then to manage mother and fetus appropriately. Thrombocytopenia in pregnancy is associated with adverse maternal and fetal outcome in significant number of pregnant woman.

Objectives: The objective of this study is to determine the frequency of factors leading to gestational diabetes mellitus and fetomaternal outcomes. Setting: Department of Obstetrics and Gynaecology Unit-II at Liaquat University Hospital Hyderabad. Study Design:  Cross sectional study. Duration of Study: Six months (1st July 2017 to 31st December 2017). Subject and Methods: A total of 86 Women with GDM included in the study by identification of risk factors from history an examination. A sample of capillary blood was tested with glucometer for random blood sugar level. GDM was diagnosed 2 hours blood glucose more than 126 mg/dl.Women with GDM was evaluated and followed to see the maternal outcome i.e. preterm delivery, pre-eclampsia and operative delivery and fetal outcome i.e. congenital anomalies, live birth, still birth, early neonatal death and macrosomia. All the data was entered on a pre-designed proforma attached at the end of synopsis. Results: The average age of the women was 26.23±4.03 years.  Frequency of factors leading to gestational diabetes mellitus was previous history of previous GDM; 66.3%, Previous history of macrosomia54.7%, Polyhydramnios in current pregnancy 51.2%, macrosomia in current pregnancy 44.2%,  previous history of shoulder dystosia 41.9%, and women with BMI >25kg/m2was observed in 32.6% cases. GDM causes significant maternal and fetal complications including preeclampsia 51.2%, preterm 23.3%, and operative delivery 29.1% as well as fetal death was observed in 21(24.4%) in which 17.44% still birth (15/86) and 6.98 (6/86) were neonatal death. Conclusion: Gestational Diabetes Mellitus is associated with increased morbidity in mothers and fetus. Early detection and intervention is important because it improves pregnancy outcome.