ORIGINAL PROF-3579 ABSTRACT… Introduction: Coronary artery bypass surgery is associated with post-operative complications like, atelactasis, pneumonia, plural effusion, pulmonary edema which effect on post operative oxygenation of patient resulting in delayed recovery and prolong hospital stay. Materials and method: A total of 170 patients included in the study. Study Design: Randomized control trial.

ABSTRACT… Introduction: Subarachnoid block has been in practice for below umbilical surgery more than 110 years.1 in recent era all over the world most of cesarean sections are being done under subarachnoid block because of high mortality rate associated with general anesthesia due to failed intubation and aspiration pneumonia. Objectives: To compare the efficacy of phenylephrine versus ephedrine in the treatment of hypotension during cesarean section under subarachnoid block. Study Design: Randomized control trial. Setting: Department of Anesthesiology Nishter Hospital Multan. Period: March 2014 to August 2014. Materials and Methods: A total 80 patients included in the study and patients were divided into two equal groups. Phenylephrine group (P group) and Ephedrine group (E group), 40 patients in each. Results: A total of 80 (100%) patients included in the study. As concern to the age of patients, mean age in group E was 30.50 and standard deviation was 5.383, similarly in group P mean age was 30.75 and SD was 5.921. As concern to the efficacy in group E, 7 were having good efficacy and 33 were have poor efficacy. In group P 30 had good efficacy and 10 had poor efficacy. P=0.000 a significant value. Conclusion: Phenylephrine is more effective than ephedrine for the treatment of hypotension due to subarachnoid block during cesarean section. Key words:Cesarean Section, Spinal Anaesthesia, Subarachnoid Block, Phenylephrine, Ephedrine. Article Citation: Nabeel SH, Furqan A, Fayyaz A, Akhtar R. Subarachnoid Block; Comparison of efficacy of phenylephrine versus ephedrine in the treatment of hypotension during subarachnoid block in C-Section. MBBS, MCPS

ObjectiveTo assess the effect of intravenous dexmedetomidine on subarachnoid anesthesia with the help of hyperbaric bupivacaine when administered as a bolus or as an infusion.Materials and methodsThis randomized control trial was conducted at the Department of Anesthesia, Nishtar Hospital, Multan, Pakistan, from January 2017 to December 2018. Seventy patients were enrolled in the study. Patients were segregated into three groups. At the T10 level, a sensory blockade was noted. The motor blockade was also periodically measured until a modified Bromage score of three was achieved. The depth of sedation was measured with the help of the Ramsay Sedation Scale score. Oxygen saturation and other factors were also measured and recorded. Nausea, vomiting, diarrhea, and pruritus were the adverse effects noted during the study. To check and compare the statistical differences among the variables from different groups, the Chi-square test and analysis of variance test were performed. A probability (p) value of <.05 was considered statistically significant.ResultsThe duration of the sensory blockade was shortest in the control group receiving only bupivacaine (Group B) and longest in the group receiving bupivacaine plus dexmedetomidine as a single bolus (Group BDexB; p: <.001). The time of complete sensory and motor recovery was longest in Group BDexB and shortest in Group B. The difference was statistically significant (p: <.001). The Ramsay score was >2 (i.e., 3 or 4) in five patients from Group B, 19 from Group BDexB, and 17 from the group receiving intrathecal bupivacaine plus dexmedetomidine as an infusion (Group BDexI). Between these groups, a statistically significant difference was found (p: <.001).ConclusionsIntravenous administration of dexmedetomidine as either a bolus or infusion prolonged the duration of the sensory and motor blockade.

Introduction: Subarachnoid block has been in practice for below umbilicalsurgery more than 110 years.1 in recent era all over the world most of cesarean sections arebeing done under subarachnoid block because of high mortality rate associated with generalanesthesia due to failed intubation and aspiration pneumonia. Objectives: To compare theefficacy of phenylephrine versus ephedrine in the treatment of hypotension during cesareansection under subarachnoid block. Study Design: Randomized control trial. Setting:Department of Anesthesiology Nishter Hospital Multan. Period: March 2014 to August 2014.Materials and Methods: A total 80 patients included in the study and patients were divided intotwo equal groups. Phenylephrine group (P group) and Ephedrine group (E group), 40 patientsin each. Results: A total of 80 (100%) patients included in the study. As concern to the age ofpatients, mean age in group E was 30.50 and standard deviation was 5.383, similarly in groupP mean age was 30.75 and SD was 5.921. As concern to the efficacy in group E, 7 were havinggood efficacy and 33 were have poor efficacy. In group P 30 had good efficacy and 10 hadpoor efficacy. P=0.000 a significant value. Conclusion: Phenylephrine is more effective thanephedrine for the treatment of hypotension due to subarachnoid block during cesarean section.