An easy, specified, accurate, precise and reproducible quantitative analyses for determination of celiprolol hydrochloride drug by used used zero, first, second and third order derivative and peak area spectrophotometry method. The suggest methods determined the drug in the concentration range (0.5-30) μg.mL−1, at 286.6 nm for 0th order, at 306.6 and 272.2 nm for 1st order, at 319.2, 289.8 and 250.2 nm for 2nd order and at 325.6, 304.8, 242.2 and 219.6 nm for 3rd order derivative spectrophotometry, respectively. The peak area spectrophotometry method also used in the same range for determining celiprolol hydrochloride, at (284.4-379.2) and (248.6-284.4) nm for 1st order, at (306.4-372.2), (271.2-306.4) and (239.4-271.2) nm for 2nd order, and at (318.6-363.8), (290.4-318.6), (233.2-250.4) and (210.8-233.2) nm for 3rd order, respectively. The accuracy and precision of the methods used was calculated and the results were highly satisfactory. The limit of detection (LOD) and limit of quantification (LOQ) was calculated for the suggested methods, Where (LOD) was within range (0.0124-0.0632) μg.mL−1, and (LOQ) within range (0.0415-0.1632) μg.mL−1. The methods were successful in application when estimating celiprolol hydrochloride drug on some pharmaceutical tablets available in the local markets.

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In this paper; a modern method was used to remove the Gentian violet dye (GV) from its aqueous solutions by chemometric separation. The Nano charcoal activated (NCA) was used to remove the GV, and the factors affecting the adsorption process were studied simultaneously to reduce the number of experiments followed and to rely on a central composite design which type CCD and the method of response surface by used STATISTICA 12 program. That gives the relationship between all the variables simultaneously. It was found that, the optimum removal efficiency reached 98.042% and it was obtained under the following conditions; The initial concentration of (GV) 12.086 mg/L, Amount of Nano charcoal activated 0.371 g, pH 7.567, Shaking time 22.934 min, and Temperature 312.092 K.

In this paper; the modern method was used to remove the congo red dye (CR) from its aqueous solutions by chemometric separation. The nano charcoal activated (NCA) was used to remove the CR and the factors affecting the adsorption process were studied simultaneously to reduce the number of experiments followed and to rely on central composite design and the method of response surface by used statistica 12 program. This gives the relationship between all the variables simultaneously. It was found that the removal efficiency reached to 98.371%.

Because health resources are limited, low-income conditions demand affordable technological development. The design and analysis is a low-cost colorimetric method for non-invasive diabetic diagnostic monitoring by glucose detection of the saliva and blood discussed, where a new compound (HAZM) was prepared through a reaction 4-aminoantipyrine with 1-phenyl-2-methyl-5-pyrazolon; FTIR, 1HNMR, and 13CNMR diagnosed for this synthetic compound. Samples have been processed and analyzed using the production equipment using glucose oxidase (GO) and peroxidase (PO) enzymes reaction with (HAZM); give the method the ability to calculate glucose level in less than 15 seconds accurately. The slope of the calibration curve is equal to 0.0026, ε = 468.26, and Sandel sensitive equals 0.384 mg/dL, to quantify the glucose salivary concentrations and blood (5-500 mg/dL) at 423 nm. Achieve a detection limit of 0.421 mg/dL where 5 % CV to (n = 3). Because HAZM tests performed according to a kit method, which reflects the mean kit values (101.35 ± 3.647 mg/dL) and the results of HAZM (104.41 ± 4.951 mg/dL) with 3.1 mg/dL positive bias in blood. Comparing the mean kit and HAZM glucose levels in saliva, 99.48 ± 1.26, and 100.97 ± 2.38 mg/dL, respectively, shows 1.5 mg/dL positive bias for the kit process. Results from the use of this method for measuring glucose in blood and saliva samples indicate that it is effective, as it offers accurate, and its cheap results compared to other commercial techniques.