Background: Tamoxifen, used as adjuvant therapy for carcinoma breast in postmenopausal women to prevent relapse has estrogenic effect on the endometrium. Methods: 104 patients on tamoxifen for more than six months were subjected to a clinical examination and transvaginal sonography. Patients with endometrial thickness > 8 mm were further evaluated by hysteroscopy and endometrial biopsy. Results: 35(34%) patients were symptomatic. The average endometrial thickness was 11.2 mm which correlated with duration of tamoxifen use. 27(48%) patients had abnormal hysteroscopic findings. 35 (63%) of endometrial biopsies revealed abnormal endometrium. One case of endometrial carcinoma was diagnosed. The results were statistically analysed. There is a significant association between symptomatic status and endometrial thickness and duration of tamoxifen use. Conclusion: All patients on long term tamoxifen should be annually screened for endometrial pathology. MJAFI 2005; 61 : 313-315

Ovarian Hyperstimulation Syndrome (OHSS) is a known iatrogenic complication of ovulation induction. Our experience of such complication while managing basic assisted conception cycles has been analysed in the present stud}'. 12 such cases were identified in 976 cycles studied gil'ing an overall incidence of 1.22%. All the cases were of mild to moderate variety and were managed conservatively, The duration of the complication ranged between 10 days to 6 weeks. Polycystic ovarian disease, LH : FSH ratio of more than 1, presence of four or more secondary follicles were found to be important predictive criteria. Identification of predictive factors of OHSS can be helpful in taking due care while using ovulation inducing drugs. Conception does worsen OHSS, but termination is usually not necessary.

The concept of supplying safe and screened blood to casualties in war has been a problem over the years. Using the equipments available in a Corp Blood Supply Unit, we describe a simple modification of a vehicle for blood supply and its potential use as a mobile blood bank.

Pre-eclampsia is a pregnancy specific syndrome characterised with hypertension, proteinuria and in severe cases manifest as hepatic, renal or CNS symptoms. Extensive studies on the etiological factors behind said syndrome have been carried out for the last three decades, however concrete evidence based information on its aetiopathogenesis is yet to be presented. The manifestations of Pre-Eclampsia, generally seen after 20 weeks of gestation, have been reported due to amalgamation of two major pathological events namely placental hypoperfusion and endothelial cell injury and leading to the advancement of the disease. The main objective of this study is to review the recent reports & hypothesis regarding aetiology and pathophysiology of Pre-eclampsia and present an overview on viability of reported hypothesis based on the cumulative opinion to provide evidenced based knowledge on the various factors that may contribute and cause the aforesaid syndrome. The review suggests that development of preeclampsia involves interaction of many physiological processes resulting from altered hemodynamics attributed to circulatory biomarkers which in turn produce profound influence on blood flow and arterial blood pressure regulation. We also hypothesize that complete profile of vasoactive biomarkers needs to be evaluated in order to explore their pathophysiological role in aetiopathogenesis of preeclampsia. This paper thus provides scope for further research to study the effects of interplay of uteroplacental factors in the pathophysiology of preeclampsia.