Schistosomiasis is a serious parasitic infection affecting millions worldwide. This study aimed to explore the anti-schistosomal activity of curcumin and curcumin loaded gold-nanoparticles (Cur-GNPs) with or without praziquantel (PZQ). We used six groups of the C57BL/6 mice in which five groups were infected with Schistosoma Mansoni (S. mansoni) cercariae and exhibited, separately, to different treatment regimens of curcumin, curcumin loaded nanoparticle, and PZQ, in addition to one untreated group which acts as a control. Mice were sacrificed at the 8th week where both worms and eggs were counted in the hepatic and porto-mesenteric vessels in the liver and intestine, respectively, in addition to a histopathological examination of the liver granuloma. Curcumin caused a significant reduction in the worms and egg count (45.45%) at the 3rd week. A significant schistosomicidal effect of PZQ was found in all groups. Cur-GNPs combined with PZQ 97.4% reduction of worm burden in the 3rd week and the highest reduction in the intestinal and hepatic egg content, as well, besides 70.1% reduction of the granuloma size. The results suggested the curcumin in combination with PZQ as a strong schistosomicidal regimen against S. mansoni as it alters the hematological, biochemical, and immunological changes induced.

Demodex is a permanent ectoparasite of the pilo-sebaceous units, related mainly to the facial region. Two species are specific for humans, Demodex folliculorum and D. brevis.Some of these species appear to be associated with variable skin disorders, yet controversy persists concerning this issue. Some reports indicate a connection between acne vulgaris and demodicosis. Aim of the work: to evaluate variable methods to expose Demodex mites. Patients and Methods : A total of 60 cases enrolled in the study were divided into 2 categories; 30 patients with acne vulgaris and 30 healthy volunteers. Samples were collected by three different methods: deep skin scraping, hair epilation and Scotch adhesive tape method.

Freshwater snails have significant consideration as they may act as intermediate hosts of several parasitic infections, mainly trematodes that may cause serious diseases in humans and domestic animals. In Egypt, these are most notably schistosomiasis and fascioliasis. The aim of this study is to survey and examine fresh water snails in some water courses of rural districts at Al-Fayoum governorate for the presence of parasitic infective stages. Eight different watercourses were involved in this study. Snail sampling was conducted seasonally between spring 2018 to winter 2019. Eleven Trematode species of fresh water snails were detected in the chosen watercourses, out of them only 5 speies were naturally infected with trematodes, (e.g. B.alexandrina with Schistosoma mansoni, B. trancatus with S. haematobium). Informationgained from such studies supposed to help in giving indication on the risk sites and times where the snail vectors of trematodes should be attacked.