In vivo assessment of the antischistosomal activity of curcumin loaded nanoparticles versus praziquantel in the treatment of Schistosoma mansoni

Mokbel, Kamal El-Din M.; Baiuomy, Ibrahim R; Sabry, Abd El-Hamid; Mohammed, Mona M; El-Dardiry, Marwa A

doi:10.1038/s41598-020-72901-y

Cited by 22 publications

(8 citation statements)

References 53 publications

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“…The worm reduction rates of Cur and Cur-Nano were 40.06 & 62.19, respectively. This agreed with Mokbel et al (2020). Magalha-es et al (2009) reported that Cur treatment modulated humoral and cellular immune responses of Schistosoma mansoni-infected mice and led to a significant reduction of parasite burden and liver pathology.…”

Section: Discussionsupporting

confidence: 82%

“…Unfortunately, the therapeutic abilities of Cur are limited because of its poor solubility or stability in aqueous media and body flulow bioavailability (Tiwari et al, 2017). This was overcome by nanotization of Cur; which improved water solubility, bioavailability, plasma concentration, cellular permeability and enhances its activity against various microbial pathogens and parasites (Mokbel et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

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Curcumin Nanoparticles Versus Curcumin in Amelioration of Inflammatory and Pathological Changes During the Migratory Phase of Murine Trichinellosis

Atia

Abokhalil

Sweed

et al. 2021

Journal of the Egyptian Society of Parasitology

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Trichinella spiralis can cause systemic inflammatory manifestations all over the body before habituating their destination in the striated muscles. Its new borne larvae (NBL) most dangerous phase go via bloodstream of different organs during migration.This study explored the anti-inflammatory, antioxidant and anti-apoptotic effects of Curcumin (Cur) and Curcumin nanoparticles (Cur-Nano) on inflammatory and pathological changes occurred in different organs in murine trichinellosis during larval migratory phase.Forty ( 40) male Swiss albino mice were divided into four groups of ten mice each. GI: mice infected and treated with Cur, GII: mice infected and treated with Cur-Nano, GIII: infected nontreated mice (positive control) and GIV: non-infected non-treated (negative control). Mice were infected orally with 200 T. spiralis larvae per mouse. GI & GII received treatment on 13 th day post infection (dpi) for 5 successive days. All mice were sacrificed on the 30 th dpi. Effects of Cur & Cur-Nano were evaluated by counting T. spiralis encysted larvae in muscle by light microscope. Frozen sera (-20°C) were used for quantitative estimation of ALT, AST, TNF sforming growth factor--) and Troponin (Trop). Specimens of lung, liver, brain and heart were fixed in neutral buffered formalin for H&E and immunohistochemical staining.The results showed that number of encysted T. spiralis larvae in GI & GII was significantly reduced compared to GIII. In both treated groups (GI & GII), there was a significant reduction in -& Trop. There was significant improvement of bile duct injury and proliferation, alveolar and pleural inflammation, and bronchial epithelial proliferation, as well as improvement of degenerative changes in brain and heart. The infected nontreated group (GIII) showed significant overexpression of Cyclooxygenase-2 (COX 2 ), caspase 3, glial fibrillary acidic protein (GFAP), arginase and granzyme b, with a significant low expression of peroxisome proliferator-activated receptors (PPARs) as compared to treated groups.

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Curcumin Nanoparticles Versus Curcumin in Amelioration of Inflammatory and Pathological Changes During the Migratory Phase of Murine Trichinellosis

Atia

Abokhalil

Sweed

et al. 2021

Journal of the Egyptian Society of Parasitology

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“…70 This in turn causes in situ lessening of the eggs’ ability to induce granulomata. Mokbel et al, 2020, 81 reported similar histopathological effects when testing the antischistosomal activity of curcumin-loaded nanoparticles, especially when combined with PZQ.…”

Section: Electron Microscope Studiesmentioning

confidence: 87%

The Idiosyncratic Efficacy of Spironolactone-Loaded PLGA Nanoparticles Against Murine Intestinal Schistosomiasis

Hady¹,

El-Emam²,

Saleh³

et al. 2023

IJN

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Background Schistosomiasis is a chronic debilitating parasitic disease accompanied with severe mortality rates. Although praziquantel (PZQ) acts as the sole drug for the management of this disease, it has many limitations that restrict the use of this treatment approach. Repurposing of spironolactone (SPL) and nanomedicine represents a promising approach to improve anti-schistosomal therapy. We have developed SPL-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) to enhance the solubility, efficacy, and drug delivery and hence decrease the frequency of administration, which is of great clinical value. Methods The physico-chemical assessment was performed starting with particle size analysis and confirmed using TEM, FT-IR, DSC, and XRD. The antischistosomal effect of the SPL-loaded PLGA NPs against Schistosoma mansoni ( S. mansoni )-induced infection in mice was also estimated. Results Our results manifested that the optimized prepared NPs had particle size of 238.00 ± 7.21 nm, and the zeta potential was −19.66 ± 0.98 nm, effective encapsulation 90.43±8.81%. Other physico-chemical features emphasized that nanoparticles were completely encapsulated inside the polymer matrix. The in vitro dissolution studies revealed that SPL-loaded PLGA NPs showed sustained biphasic release pattern and followed Korsmeyer–Peppas kinetics corresponding to Fickian diffusion ( n <0.45). The used regimen was efficient against S. mansoni infection and induced significant reduction in spleen, liver indices, and total worm count ( ρ <0.05). Besides, when targeting the adult stages, it induced decline in the hepatic egg load and the small intestinal egg load by 57.75% and 54.17%, respectively, when compared to the control group. SPL-loaded PLGA NPs caused extensive damage to adult worms on tegument and suckers, leading to the death of the parasites in less time, plus marked improvement in liver pathology. Conclusion Collectively, these findings provided proof-of-evidence that the developed SPL-loaded PLGA NPs could be potentially used as a promising candidate for new antischistosomal drug development.

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“…In another study of combination drugs, Mokbel et al (2020) evaluated the use of curcumin‐loaded gold nanoparticles, a molecule present in the Curcuma longa plant, with or without praziquantel. Oral treatment of S. mansoni ‐infected mice using curcumin‐loaded gold nanoparticles combined with praziquantel caused a high reduction in worm burden (97.4%).…”

Section: Oral Drug Delivery System For the Treatment Of Ntdsmentioning

confidence: 99%

Recent approaches in nanocarrier‐based therapies for neglected tropical diseases

Mengarda

Iles

Longo

et al. 2022

WIREs Nanomed Nanobiotechnol

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Neglected tropical diseases (NTDs) remain major public health problems in developing countries. Reducing the burden of NTDs requires sustained collaborative drug discovery efforts to achieve the goals of the new NTDs roadmap launched by the World Health Organization. Oral drugs are the most convenient choice and usually the safest and least expensive. However, the oral use of some drugs for NTDs treatment has many drawbacks, including toxicity, adverse reactions, drug resistance, drug low solubility, and bioavailability. Since there is an imperative need for novel and more effective drugs to treat the various NTDs, in recent years, several compound‐loaded nanoparticles have been prepared with the objective of evaluating their application as an oral drug delivery system for the treatment of NTDs. This review focuses on the various types of nanoparticle drug delivery systems that have been recently used against the major NTDs caused by parasites such as leishmaniasis, Chagas disease, and schistosomiasis. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease

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In vivo assessment of the antischistosomal activity of curcumin loaded nanoparticles versus praziquantel in the treatment of Schistosoma mansoni

Cited by 22 publications

References 53 publications

Curcumin Nanoparticles Versus Curcumin in Amelioration of Inflammatory and Pathological Changes During the Migratory Phase of Murine Trichinellosis

Curcumin Nanoparticles Versus Curcumin in Amelioration of Inflammatory and Pathological Changes During the Migratory Phase of Murine Trichinellosis

The Idiosyncratic Efficacy of Spironolactone-Loaded PLGA Nanoparticles Against Murine Intestinal Schistosomiasis

Recent approaches in nanocarrier‐based therapies for neglected tropical diseases

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