Novel naphthalene-heterocycle hybrids were synthesized via tandem reactions of 3-formylchromone with different nucleophilic reagents. Various hybrids revealed potent antitumor and anti-inflammatory as well as promising antituberculosis activities.

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A new promising protocol has been developed for the synthesis of scarce oxocine derivatives through addition of amine-based nucleophiles to chromonylidene benzothiazol-2-ylacetonitrile under metal free reaction conditions in moderate to good yields.

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