Improving yield and its components for some sesame genotypes using potassium fertilizer application under salt-affected soil was the desired goal of this study. So, for each site i.e. non-saline site, moderately-saline site and highly-saline site, the experiment was performed in a randomized complete block design (RCBD) using split-plot arrangement with three replications at the Investigational Farm of Tag-El-Ezz Agricultural Research Station, Dakahlia Governorate, Agricultural Research Center, Egypt during 2018 and 2019 successive summer seasons. Three levels of potassium fertilizer i.e. 0, 25 and 50 kg K 2 O fed-1 were assigned in the main plots and three sesame varieties i.e. Shandaweel 3, Giza 32 and Sohag 1 were arranged in the sub-plots. The main effects of sites, potassium fertilizer levels, sesame varieties and their dual and triple interactions were highly significant for all the studied traits. Shandaweel 3 was more salt tolerant variety and it was relevant to grow under salt stress. The potassium rate of 50 kg K 2 O fed-1 was found to be more efficient to mitigate salinity effect and increase yield and its components under salt stress. Therefore, Shandaweel 3 could be recommended under salinity stress with adding 50 kg K 2 O fed-1 to get high yield with high quality and nutrition value.