Background: The most frequent cancer in women is breast cancer (BC), which unfortunately have a high mortality in Sudan whereas the most of patients are diagnosed at late stages of this disease sequence either due to a lack of awareness or unviability of screening programs. objective: to asses of the knowledge and awareness of breast cancer detection among Sudanese women 2022 - 2023. Material and Methods: a community representative descriptive cross - sectional study of women aged 17 to 70 years in different Sudanese provinces were included using semi-structural interviewed questionnaire. Results: out of 200 participants, mean age 39.8 (±12.13) years and the majority of them were aged between 41 and 50 years 54 (27%). 120 (60%) had no prior experience with breast cancer at all and 73 (36.5%) had never heard of breast self-examination for BC. The study resulted that the dominant of interviewed women 181 (90.5%) had a good awareness of breast cancer, 161 (80.5%) believed that breast screening must require for early detection of breast tumors. Breast changes, discharge and lump pain were the common prevalent reasons for breast screening in this study 95 (38.7%), 46 (18.7%) and 45 (18.3). It was clear that education level has a significant effect in the level of knowledge of breast cancer and its diagnostic screening tools among participants, with graduated women having adequate knowledge in comparison to whom not graduated women 92 (50.5%) and 89 (49.2%) (p value = 0.004 < 0.05). As well, the central resident participants had a good knowledge about breast cancer 112 (70 %) in compare with other residents. Conclusion: awareness and knowledge of BC detection increase with increasing educational level and central urban living, there is an urgent need for an intensive breast cancer awareness programs and the availability of screening centers authorities in Sudanese periphery areas.