Background and Objectives: Sleep is a complex biological process. Early insomnia is one of the most common problems among young people. This study aims to investigate the sleep-wake pattern of adolescents in Makran region of Sistan and Baluchestan province, Iran Methods: In this descriptive study, 530 high school students in Makran region of Sistan Baluchestan province (three main cities of Saravan, Iranshahr, Chabahar) in the academic year 2019-2021 were selected by a multi-stage sampling method. They completed a demographic form and the morningness-eveningness questionnaire (MEQ). Data were analyzed in SPSS softwareو version 21 software using independent t-test and ANOVA. Results: The students had moderate circadian rhythm, but sleep preferences were reported in these students mostly among boys. The preferred pattern of students in Iranshahr, Saravan and Chabahar cities was the sleep preference. The wake preference, sleep preference, and peak performance preference of students in Iranshahr were lower than in Saravan and Chabahar cities. Conclusion: The sleep-wake pattern of adolescent students in Makran region of Sistan Baluchestan province is at a moderate level, and all students prefer the sleep pattern over other patterns. It is recommended that the circadian rhythms of these students should be investigated and the necessary measures should be taken to inform their parents and adjust the school and home schedule so that the students have better sleep.