Background Glaucoma in adults is a leading eye disease that causes blindness. Its management is life long and both surgical and medical treatment options are available to manage this ailment. Patients and their caregiver's cooperation in instilling timely eye drops is crucial for the effective reduction of intraocular pressure (IOP) and by halting/delaying the progression of visual disabilities due to glaucoma. Periodic assessment and strict adherence to medical treatment has been found to be less than desired. It is influenced by the severity of the disease, the duration of the ailment, the number of eye drops being used, the literacy level, and the cost of medication. We present the adherence rate of topical medications and its determinants among adult Saudi glaucoma patients getting treated in 2017 in a tertiary eye center in Saudi Arabia.

Advancements in internet technology are on the rise and so is the concern for its detrimental effects on youth like cyberbullying. Cyberbullying is on the rise and may cause adverse effects on mental health. The objective of the present study was to identify the prevalence of cyberbullying and its associated risk factors and to measure its association with mental health among adolescents. MethodsAn online self-administered questionnaire was distributed to 761 high school students aged 15 -19 years from Riyadh, Saudi Arabia. A quantitative cross-sectional design was integrated, and logistic regression analysis was performed to determine the association. As part of assessing mental health, a questionnaire on the use of cigarettes, e-cigarettes, and hookah was also administered. ResultsThe prevalence of cyberbullying was 18%. Although a significant association between cyberbullying and mental health status was obtained (OR = 1.04; p =0.03), the risk of Odds was found to be weak and therefore did not favor the hypothesis. The significant risk factors associated with cyberbullying include being traditionally bullied (OR= 4.76; p = <.001), e-cigarette use (OR = 2.73; p = <.001), and male gender (OR = 1.64; p = .04). ConclusionDespite the findings not favouring the hypothesis, a few striking associations were obtained in the study. Traditional bullying and e-cigarette use increased the risk of cyberbullying. This is a matter of rising concern since e-cigarette use has witnessed a surging rise in popularity. These findings may serve as early warning on the rising issue of cyberbullying and could pave way for formulating early preventive strategies and promulgate awareness by the concerned authorities.

Background: The JAK2 V617F mutation’s discovery has largely facilitated the comprehension of the myeloproliferative neoplasms’(MPNs) pathogenesis. In recent times, calreticulin (CALR) mutations have been detected in patients with JAK2V617F negative primary myelofibrosis (PMF), and essential thrombocythemia (ET). Methods: This study analyzed the impact of JAK 2 Exon 12 and CALR common mutations in 65 patients with JAK2V617F negative MPN from the Jeddah region. An allele-specific polymerase chain reaction (PCR) method was used to screen four common mutations on Exon 12 and direct sequencing and PCR analysis were utilized to screen all patients for CALR. Results: None of the patients were positive for the Exon 12 mutation and eight patients were positive for CALR mutations. Conclusions: This is the first Saudi Arabian research that focused on screening CALR hotspot mutations and this mutation exists. This fact highlights the importance of implementing diagnostic screening of CALR on MPN patients, in general, and patients with high platelet count, in particular. Further screening of other predisposing genetic markers might facilitate the identification of an important genetic variant, which could aid in the understanding of disease pathogenesis.

Saudi Arabia has an alarmingly high incidence of cardiovascular disease (CVD) and its associated risk factors. To effectively assess CVD risk, it is essential to develop tailored models for diverse regions and ethnicities using local population variables. No CVD risk prediction model has been locally developed. This study aims to develop the first 10-year CVD risk prediction model for Saudi adults aged 18 to 75 years. The electronic health records of Saudi male and female patients aged 18 to 75 years, who were seen in primary care settings between 2002 and 2019, were reviewed retrospectively via the Integrated Clinical Information System (ICIS) database (from January 2002 to February 2019). The Cox regression model was used to identify the risk factors and develop the CVD risk prediction model. Overall, 451 patients were included in this study, with a mean follow-up of 12.05 years. Thirty-five (7.7%) patients developed a CVD event. The following risk factors were included: fasting blood sugar (FBS) and high-density lipoprotein cholesterol (HDL-c), heart failure, antihyperlipidemic therapy, antithrombotic therapy, and antihypertension therapy. The Bayesian information criterion (BIC) score was 314.4. This is the first prediction model developed in Saudi Arabia and the second in any Arab country after the Omani study. We assume that our CVD predication model will have the potential to be used widely after the validation study.

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