Aim: To evaluate the response of intraoral soft tissue by low level laser light, histologically and biochemically. Materials and methods: The study was performed on (20) healthy rats. A clean two sided mucoperiosteal flap was raised opposite to the area of lower incisors. The rats were divided into two groups, ten for each. Histological specimens were taken at days 5 th ,9 th and 11 th postoperative period .The dose of laser therapy in each session was 0.75 J/cm 2. Each rat in each group received this dose daily for 11 th days at an interval of 15 minutes. Histopathological analysis were made for both groups detecting number of blood vessels (neovascularization),collagen arrangements and number of fibroblasts. Biochemical analysis of C-reactive protein(CRP) was also conducted. Results: Laser therapy showed enhancement of neovasculazation at days 5and 9 postoperatively .While collagen arrangement showed significant changes at the 5 th ,9 th and 11 th postoperative days. Biochemical analysis showed significant increase of CRP at the 5 th postoperative day. This increase was followed by a significant decrease at the 7 th postoperative day in comparison with the control group. Conclusion: The present results indicated that low level laser therapy at a dose of 0.75 J/cm 2 enhanced wound healing .