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To evaluate the affects of sizes of fibroids in post-menopausal females. Material and method: Data for this article was extracted from google scholar and PubMed, including 28 articles published from 2003 to 2020. Conclusion: Uterine fibroids are benign tumors that affect women throughout their reproductive years, peaking in the perimenopausal years.In postmenopausal women, the incidence of Uterine fibroids reduces. Medical treatment of Uterine fibroids may provide symptom alleviation and serve as a transition into menopause.Although it is true that Uterine fibroids regress with the onset of menopause, this does not occur in all cases. The most successful treatment to date is hysterectomy.More study is needed to better understand the pathophysiology of Uterine fibroids and to identify risk factors.