Cyclisation of [4-(4-oxo-2-phenyl-4H-quinazolin-3-yl)-phenoxy]-acetic acid-N'-(substituted phenyl)-thiosemicarbazides with sodium metal in 99.0 % ethanol gave 3-[4-(4-substituted phenyl-5-thioxo-4,5-dihydro-1H-1,2,4 triazol-3-ylmethoxy)- phenyl]-2-phenyl-3H-quinazolin-4-one . The structures of the newly synthesized compounds have confirmed by IR,1H NMR and Mass spectra. The compounds have also been screened for their biological activity.

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4-(4-Oxo-2-phenyl-4H-quinazolin-3-yl)-phenoxy]-acetic acid [2-oxo-l,2-dihydro-indol-3-ylidene]-hydrazide (7) on reaction with formaldehyde and various secondary amines in Ν,Ν-dimethyl formamide afforded Mannich bases [4-(4-oxo-2-phenyl-4H-quinazolin-3-yl)-phenoxy]-acetic acid [1-substituted aminomethyl-2-oxo-l,2-dihydro-indol-3-ylidene]-hydrazides (8a-d). The structures of the newly synthesized compounds have been confirmed by IR, *H NMR and mass spectra. The compounds have also been screened for their biological activity. Keywords : [4-(4-oxo-2-phenyl-4H-quinazolin-3-yl)-phenoxy]-acetic acid ethyl ester, lH-indole-2,3-dione, IR, spectral studies and biological activity.