Objective: To determine the diagnostic accuracy of doppler ultrasound in the diagnosis of testicular carcinoma, by taking histopathology as gold standard. Methods: This cross-sectional study was carried out at Radiology department of Liaquat University of Medical and health Sciences (LUMHS), from November 2017 to October 2019. All the clinically diagnosed cases of testicular carcinoma, those who referred for doppler ultrasound and histopathology of testes, were included. After taking informed consent all the study participants underwent testicular histopathology after doppler ultrasound. All of the information was entered into a research proforma. SPSS version 20 was used to analyze the data. Results: Overall, 70 patients of suspected testicular carcinoma were studied. The mean age of the cases was 38.38+4.55 years. Most of the cases 47(67.1%) were poor. As per Doppler ultrasound (U/S) findings out of all 55.7% cases had diagnosed testicular carcinoma, while histopathologically it was observed in 45.7% of the cases. Diagnostic accuracy of Doppler U/S in testicular carcinoma diagnosis was observed to be 77%, followed by sensitivity (SE) 84%, specificity (SP) 71%, positive predictive value (PPV) 78% and negative predictive value (NPV) 84%. Conclusion: Doppler ultrasound observed to be a non-invasive, uncomplicated, lack of pain, effective and easily available diagnostic tool for early diagnosis of testicular carcinoma.

Objective: To determine the ddiagnostic accuracy of susceptibility weighted magnetic resonance imaging (SW-MRI) for glioblastoma diagnosis by taking biopsy as gold standard. Material and Methods: This cross-sectional study was done at department of Radiology, Jinnah Postgraduate Medical Center (JPMC), Karachi from June to December 2017. Total 114 cases with focal neurological deficit, seizures, stroke and CT scan findings of a mass with irregular thick margins and symptoms of increased intracranial pressure were enrolled. All the study subjects undergone SWI MRI. Brain biopsy was done during the same period of hospitalization. All the data was collected by study proforma and analysis of data was done by SPSS version 26 Results: Total 114 cases were studied and mean age of the cases was 50.64+10.37 years. Males were in majority 60.5% and females were 39.5%. Lesion average size was 4.34 cm. Glioblastoma was diagnosed among 68.4% cases on SW-MRI, while its was diagnosed among 71.1% study subjects by biopsy. SW-MRI showed sensitivity 90.1%, specificity 84.8%, PPV 93.5%, NPV 77.7% and diagnostic accuracy was found 88.59%. Conclusion: The SW-MRI was observed to be the best diagnostic tool for glioblastoma with diagnostic accuracy of 88.59%, sensitivity 90.1% and specificity 84.8%. This diagnostic tool may helpful to indorse the expected diagnosis in clinical practice.

Background: Retained product of conception (RPOC) has been the commonest factor involved in secondary post-partum hemorrhage. Ultrasound is a valuable diagnostic method for the diagnosis of PPH patients and is much more reliable than clinical presentation for the RPOC diagnosis alone. Objective: To determine the diagnostic accuracy of ultrasound in detection of retained products of conception in postpartum period in clinically suspected patients taking histopathology as gold standard.

Background: In the gynecologic malignancies, ovarian cancer is the 2 nd most common and a big cause of the mortality. Contrast-enhanced CT is a recent imaging technique of choice in preoperative assessment of ovarian cancer. Objective: To determine the diagnostic accuracy of contrast enhanced computed tomography of abdomen and pelvis in detection of ovarian cancer in clinically suspected patients by using histopathology as gold standard. Study Design: Cross-Sectional Study.

Objective: To evaluate the diagnostic accuracy of multislice computed tomography (CT) in detection of squamous cell carcinoma (SCC) of oral cavity in clinically suspected patients taking histopathology as gold standard. Material and Methods: This cross-sectional study has been conducted at Radiology department of Civil Hospital Karachi from 8th September 2018 to March 2019. All the cases having suspected oral squamous cell carcinoma and either of gender were included. Patients underwent computed tomography by using multislice scanner. Then patients undergone biopsy sampling and patients were labeled as positive or negative for squamous cell carcinoma of oral cavity on MDCT and histopathology. Sensitivity, specificity, and diagnostic accuracy of multislice CT for squamous cell carcinoma of oral cavity were measured taking histopathology as gold standard. Results: Total 168 cases were studied and out of them males were 76.8% and females were 23.2%. Mean gutka addiction history was 11.52±5.21 years. Mean lesion size on CT scan was 2.44±1.43 cm. In our study, 35.1% patients were diagnosed positive by multislice computed tomography and 43.5% through histopathology. Sensitivity, Specificity, PPV, NPV and accuracy were 86.4%, 79.8%, 69.9%, 91.6%, and 82.1% respectively. Conclusion: Multislice CT observed to be the effective diagnostic tool for the detection of SCC of oral cavity. Keywords: Multislice Computed Tomography, cancer, Oral Cavity