Schiff base derived from 2-aminophenol and 3-formyl-2-hydroxy-6-methoxyquinoline and its Mn(II) and Fe(II) complexes were synthesized and characterized by melting point and decomposition temperature, elemental analysis, molar conductivity, infrared (IR) spectral analysis, atomic absorption spectroscopy (AAS) analysis, solubility test, and magnetic susceptibility. The Fourier-transform infrared spectroscopy (FTIR) spectral data of the Schiff base determined showed a band at 1622 cm −1 and this was assigned to the v (C=N), which is a feature of azomethine group. The same band was observed to shift to lower frequencies 1577 and 1599 cm −1 in the complexes suggesting coordination of the Schiff base with the respective metal(II) ions. Molar conductance values 14.58 and 12.65 Ω −1 •cm 2 •mol −1 show that the metal complexes were non-electrolyte in nature. The magnetic susceptibility of the complexes was determined and the gram magnetic susceptibility of the complexes was found to be positive, revealing that they are paramagnetic. The elemental analysis of the complexes for C, N and H determined suggested 1:1 metal to ligand ratio. The result of the antimicrobial studies showed that, the metal(II) complexes exhibited better antibacterial and antifungal activity than the Schiff base.
Two hydrazone Schiff base was synthesized by the interaction of ethanolic solution of antiglyoxime hydrazine with 2-acetyl-5-methylfuran to obtain the Schiff base. The complexes of Mn(II), Fe(II), Ni(II) and Cu(II) and their Schiff base were synthesized and characterized based on solubility, percentage yield, elemental analysis, melting point and decomposition temperature, infra-red spectra (FT-IR), conductivity measurement, magnetic susceptibility and water of crystallisation. The ligand and the complexes were coloured and stable at room temperature. They were soluble in acetone, DMSO, ethanol, methanol, hexane, chloroform, carbontetrachloride, benzene and DMF but insoluble in distilled water. The melting point temperature of the ligand was 118oC while the decomposition temperatures for the complexes were found to be between 295-312oC. The molar magnetic susceptibility of the complexes were in the range of 3.55 x 10-3 – 1.42 x 10-2erg.G-2mol-1. Molar conductance values of 2.17 – 2.87Ω-1cm2mol-1 show non electrolytic nature of the complexes. The spectral data of the ligand showed bands in the range 1581–1607cm-1 revealing the formation of the azomethine group. A band between 760-795cm-1 indicates the metal nitrogen bonds. The elemental analysis of the complexes showed the metal ligand ratio of 1:2 (M:2L). The antibacterial and antifungal studies showed that the complexes exhibited higher antibacterial and antifungal activities than the ligand but lower than the reference drugs.
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