Two hydrazone Schiff base was synthesized by the interaction of ethanolic solution of antiglyoxime hydrazine with 2-acetyl-5-methylfuran to obtain the Schiff base. The complexes of Mn(II), Fe(II), Ni(II) and Cu(II) and their Schiff base were synthesized and characterized based on solubility, percentage yield, elemental analysis, melting point and decomposition temperature, infra-red spectra (FT-IR), conductivity measurement, magnetic susceptibility and water of crystallisation. The ligand and the complexes were coloured and stable at room temperature. They were soluble in acetone, DMSO, ethanol, methanol, hexane, chloroform, carbontetrachloride, benzene and DMF but insoluble in distilled water. The melting point temperature of the ligand was 118oC while the decomposition temperatures for the complexes were found to be between 295-312oC. The molar magnetic susceptibility of the complexes were in the range of 3.55 x 10-3 – 1.42 x 10-2erg.G-2mol-1. Molar conductance values of 2.17 – 2.87Ω-1cm2mol-1 show non electrolytic nature of the complexes. The spectral data of the ligand showed bands in the range 1581–1607cm-1 revealing the formation of the azomethine group. A band between 760-795cm-1 indicates the metal nitrogen bonds. The elemental analysis of the complexes showed the metal ligand ratio of 1:2 (M:2L). The antibacterial and antifungal studies showed that the complexes exhibited higher antibacterial and antifungal activities than the ligand but lower than the reference drugs.

A hydrazone Schiff base has been synthesized by the interaction of ethanolic solution of antiglyoxime hydrazine with 2-acetyl-5-methylfuran, to obtain the corresponding Schiff base L. The complexes of Ni(II) and Cu(II) of the Schiff base were synthesized and studied. The Schiff base and its metal(II) complexes characterized based on solubility, percentage yield, elemental analysis, melting/decomposition temperatures, infra- red spectral (FT-IR), conductivity measurement, magnetic susceptibility and water of crystallisation. The synthesized Schiff base and the complexes are coloured and stable at room temperature. Based on the results the prepared Schiff base and synthesized complexes are relatively soluble in most organic solvents but insoluble in distilled water. The melting point temperature of the ligand was 118oC while the decomposition temperature for metal complexes were 308 and 300oC respectively. The molar magnetic susceptibility of the complexes were 3.55 and 2.10 x 10-3 erg.G-2mol-1. The molar conductance values of 2.17 and 2.43ohm-1cm2mol-1 indicating non electrolytic nature of the complexes. The spectral data of the Schiff base showed band of 1584cm-1, revealing the formation of the azomethine. A bands of 791cm-1 indicate the metal nitrogen bond. The elemental analysis determination of the complexes and the Schiff base showed the metal ligand ratio of 1:2 (M:2L). The antibacterial and antifungal activities of the Schiff base and the metal(II) complexes were evaluated using disc diffusion method. The antibacterial assay was carried out on three pathogenic bacteria, Staphylococcus aureus, Staphylococcus epidermidis and Streptococcus pneumonia and two fungi viz: Candida utilis and Saccharomyces cerevisiae. All the Schiff base